SALT AND POLYMORPH OF BENZOPYRIMIDINONE COMPOUND AND PHARMACEUTICAL COMPOSITION AND USE THEREOF

Title:

SALT AND POLYMORPH OF BENZOPYRIMIDINONE COMPOUND AND PHARMACEUTICAL COMPOSITION AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2019/007299

Kind Code:

A1

Abstract:

Disclosed are a salt and a polymorph of a benzopyrimidinone compound and a pharmaceutical composition and the use thereof. In particular, disclosed are a hydrochloride of a benzopyrimidinone compound as shown in the following formula, (I-A), a pharmaceutically acceptable polymorph, solvate, hydrate, co-crystal, anhydride or amorphous form thereof, a pharmaceutical composition and drug unit dosage form containing same, a method for preparing the above-mentioned substances and the use thereof.

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Inventors:

SHEN JINGSHAN (CN)
HE YANG (CN)
CHEN WEIMING (CN)
LI JIANFENG (CN)
TIAN GUANGHUI (CN)
GONG XUDONG (CN)
WANG ZHEN (CN)
ZHANG RONGXIA (CN)
LIU YONGJIAN (CN)
JIANG HUALIANG (CN)

Application Number:

PCT/CN2018/093965

Publication Date:

January 10, 2019

Filing Date:

July 02, 2018

Export Citation:

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Assignee:

SHANGHAI INST MATERIA MEDICA CAS (CN)
VIGONVITA LIFE SCIENCES SUZHOU CO LTD (CN)
TOPHARMAN SHANGHAI CO LTD (CN)

International Classes:

C07D239/32; A61K31/506; A61P15/10; C07D239/36

Domestic Patent References:

WO2010066111A1	2010-06-17
WO2010066111A1	2010-06-17

Foreign References:

EP0636626A1	1995-02-01
CN1746171A	2006-03-15

Other References: