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Title:
SALT OF PYRANOSE-SUBSTITUTED HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/154388
Kind Code:
A1
Abstract:
The present application relates to a salt of a pyranose-substituted heterocyclic compound, a preparation method therefor, and use thereof, and in particular, to an acid addition salt of a compound of formula (I) or a prodrug thereof, and further relates to D-glucuronate of a crystalline compound of formula (I) or a prodrug thereof. D-glucuronate of a compound of formula (II) has particular advantages in terms of crystallizability, subsequent purification, stability, formulation medicinal properties or quality control, and is most applicable for improving the formulation pharmaceutical properties, purity and quality control, as well as large-scale process development of such drugs.

Inventors:
ZHANG, Fei (Unit 801, Building B7 BioBay, No. 218 Xing Hu Street, Suzhou Industrial Par, Suzhou Jiangsu 3, 215123, CN)
WANG, Peng (Unit 801, Building B7 BioBay, No. 218 Xing Hu Street, Suzhou Industrial Par, Suzhou Jiangsu 3, 215123, CN)
ZHU, Lin (Unit 801, Building B7 BioBay, No. 218 Xing Hu Street, Suzhou Industrial Par, Suzhou Jiangsu 3, 215123, CN)
SUN, Lili (Unit 801, Building B7 BioBay, No. 218 Xing Hu Street, Suzhou Industrial Par, Suzhou Jiangsu 3, 215123, CN)
Application Number:
CN2019/074667
Publication Date:
August 15, 2019
Filing Date:
February 03, 2019
Export Citation:
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Assignee:
YABAO PHARMACEUTICAL GROUP CO., LTD. (No.43 Fumin Road, Ruicheng CountyYuncheng, Shanxi 0, 044600, CN)
SUZHOU YABAO PHARMACEUTICAL R&D CO., LTD. (Unit 801, Building B7 BioBay, No. 218 Xing Hu Street, Suzhou Industrial Par, Suzhou Jiangsu 3, 215123, CN)
International Classes:
C07H19/04; A61K31/7042; A61P3/00
Foreign References:
CN105636972A2016-06-01
CN105593229A2016-05-18
Attorney, Agent or Firm:
PATENTSINO IP FIRM (Suite 413, Shang Fang Building No.27 North Third Ring Road Middle, Xicheng District, Beijing 9, 100029, CN)
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