Title:
SALTS OF COMPOUNDS AND CRYSTALS THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/036199
Kind Code:
A1
Abstract:
The present invention provides crystals of (1R,3R,15E,28R,29R,30R,31R,34R,36R,39S,41R)-29,41-Difluoro-34,39-bis(sulfanyl)-2,33,35,38,40,42-hexaoxa-4,6,9,11,13,18,20,22,25,27-decaaza-34λ5,39λ5-diphosphaoctacyclo[28.6.4.13,36.128,31.04,8.07,12.019,24.023,27]dotetraconta-5,7,9,11,15,19,21,23,25-nonaene-34,39-dione (Compound (I)) ammonium salts, Compound (I) sodium salts, or Compound (I), possessing a potential to be used as drug substance in pharmaceuticals.
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Inventors:
NIIJIMA JUN (JP)
KURODA HIROFUMI (JP)
YASUI SO (JP)
ITO YOKO (JP)
KUSHIDA IKUO (JP)
KURODA HIROFUMI (JP)
YASUI SO (JP)
ITO YOKO (JP)
KUSHIDA IKUO (JP)
Application Number:
PCT/JP2019/031951
Publication Date:
February 20, 2020
Filing Date:
August 14, 2019
Export Citation:
Assignee:
EISAI R&D MAN CO LTD (JP)
International Classes:
A61K31/7084; C07F9/6574; C07H19/213
Domestic Patent References:
| WO2015185565A1 | 2015-12-10 | |||
| WO2014179335A1 | 2014-11-06 | |||
| WO2014099824A1 | 2014-06-26 | |||
| WO2018152450A1 | 2018-08-23 | |||
| WO2018152453A1 | 2018-08-23 | |||
| WO2015185565A1 | 2015-12-10 |
Other References:
LIOUX,T. ET AL.: "Design, Synthesis, and Biological Evaluation of Novel Cyclic Adenosine-Inosine Monophosphate (cAIMP) Analogs That Activate Stimulator of Interferon Genes (STING", JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, no. 22, 2016, pages 10253 - 10267, XP055457763, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b01300
CORRALES L ET AL.: "The host STING pathway at the interface of cancer and immunity", J. CLIN. INVEST., vol. 126, 2016, pages 2404 - 11, XP002790392, DOI: 10.1172/JCI86892
CORRALES L ET AL.: "The host STING pathway at the interface of cancer and immunity", J. CLIN. INVEST., vol. 126, 2016, pages 2404 - 11, XP002790392, DOI: 10.1172/JCI86892
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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