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Title:
SALTS AND HYDRATES OF ANTIPSYCHOTICS
Document Type and Number:
WIPO Patent Application WO/2014/013465
Kind Code:
A3
Abstract:
The present invention relates to a novel salt of (3aR,4S,7R,7aS)-2-[((1R,2R)-2-{[4-(1,2-benzisothiazol-3-yl)-piperazin-1-yl]methyl} cyclohexyl)methyl]hexahydro-1 H-4,7-methanisoindol-1,3-dione and hydrates thereof, to methods for preparing the novel salt and its hydrates. In one aspect, the present invention provides a compound which is lurasidone dihydrochloride. In another aspect, the present invention provides a process for preparation of lurasidone dihydrochloride comprising: (i) mixing lurasidone free base in an organic solvent system; (ii) subjecting step (i) mixture to acid proton source; and (iii) isolating compound of lurasidone dihydrochloride.

Inventors:
VEERAPPAN VIJAYABASKAR (IN)
SANKARESWARAN SRIMURUGAN (IN)
VISWANATHAN SATHISH KUMAR RAMAN (IN)
SUBRAMANIAN N (IN)
Application Number:
PCT/IB2013/055908
Publication Date:
April 24, 2014
Filing Date:
July 18, 2013
Export Citation:
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Assignee:
SHASUN PHARMACEUTICALS LTD (IN)
International Classes:
A61K31/496
Domestic Patent References:
WO2012063246A12012-05-18
Foreign References:
US20050020608A12005-01-27
US20060211699A12006-09-21
CN102827157A2012-12-19
Other References:
See also references of EP 2874628A4
Attorney, Agent or Firm:
WILSON, Neeti et al. (B-41 Nizamuddin East, New Delhi 3, IN)
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