Title:
SALTS OF SUBSTITUTED 1, 2, 3, 4-TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES AS NMDA ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO/2003/013530
Kind Code:
A2
Abstract:
The invention relates to salts of substituted 1, 2, 3, 4-tetrahydroquinoline-2-carboxylic acid derivatives of formula (I), in addition to methods for the production thereof, the use thereof in he production of medicaments and medicaments containing said compounds.
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Inventors:
MAUL CORINNA (DE)
PRZEWOSNY MICHAEL (DE)
ENGLBERGER WERNER GUENTER (DE)
PRZEWOSNY MICHAEL (DE)
ENGLBERGER WERNER GUENTER (DE)
Application Number:
PCT/EP2002/008729
Publication Date:
February 20, 2003
Filing Date:
August 05, 2002
Export Citation:
Assignee:
GRUENENTHAL GMBH (DE)
MAUL CORINNA (DE)
PRZEWOSNY MICHAEL (DE)
ENGLBERGER WERNER GUENTER (DE)
MAUL CORINNA (DE)
PRZEWOSNY MICHAEL (DE)
ENGLBERGER WERNER GUENTER (DE)
International Classes:
A61K31/47; A61K31/473; A61K31/4741; A61P1/04; A61P1/12; A61P3/10; A61P9/10; A61P11/00; A61P11/14; A61P13/02; A61P15/06; A61P17/04; A61P19/10; A61P23/00; A61P25/00; A61P25/04; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/32; A61P25/36; A61P27/06; A61P27/16; A61P29/00; A61P31/18; A61P37/08; A61P43/00; C07B61/00; C07D215/48; C07D221/06; C07D221/16; C07D221/18; C07D491/04; C07D491/044; C07D491/048; (IPC1-7): A61K31/47; A61K31/4738; C07D221/16; C07D491/04; C07D221/18; A61P25/04; C07D215/48
Domestic Patent References:
| WO1998034111A1 | 1998-08-06 | |||
| WO1999064411A1 | 1999-12-16 | |||
| WO2001058875A2 | 2001-08-16 | |||
| WO1998034115A1 | 1998-08-06 |
Foreign References:
| EP0386839A2 | 1990-09-12 | |||
| US4898854A | 1990-02-06 |
Other References:
CARLING R W ET AL: "2-CARBOXYTETRAHYDROQUINOLINES. CONFORMATIONAL AND STEREOCHEMICAL REQUIREMENTS FOR ANTAGONISM OF THE GLYCINE SITE ON THE NMDA RECEPTOR" JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, Bd. 35, 1992, Seiten 1942-1953, XP001002472 ISSN: 0022-2623 in der Anmeldung erw{hnt
LEESON P D ET AL: "4-AMIDO-2-CARBOXYTETRAHYDROQUINOLINE. STRUCTURE-ACTIVITY RELATIONSHIPS FOR ANTAGONISM AT THE GLYCINE SITE OF THE NMDA RECEPTOR" JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, Bd. 36, Nr. 11, 1992, Seiten 1954-1968, XP000919439 ISSN: 0022-2623 in der Anmeldung erw{hnt
LEESON P D ET AL: "4-AMIDO-2-CARBOXYTETRAHYDROQUINOLINE. STRUCTURE-ACTIVITY RELATIONSHIPS FOR ANTAGONISM AT THE GLYCINE SITE OF THE NMDA RECEPTOR" JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, Bd. 36, Nr. 11, 1992, Seiten 1954-1968, XP000919439 ISSN: 0022-2623 in der Anmeldung erw{hnt
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