Title:
SAMPLE PLATE FOR PESI ION SOURCE AND MASS SPECTROMETER USING SAID SAMPLE PLATE
Document Type and Number:
WIPO Patent Application WO/2018/220742
Kind Code:
A1
Abstract:
This sample plate for a solid sample comprises a plate-like body (2) and a lid (3). The body (2) has a recess (21) that has a bottom surface center that protrudes in a cylindrical shape so as to form a sample stage (21a). The lid (3) has a funnel-shaped opening (31) formed therein directly above the recess (21) such that the diameter of the bottom of the opening is roughly the same as the diameter of the sample stage. When a biological tissue section or other sample (7) is accommodated in the recess (21) and the lid (3) is closed, the bottom surface wall around the opening (31) of the lid (3) pushes the sample (7) down and the sample (7) is sandwiched between the bottom surface wall and sample stage (21a). A solvent for ionization is injected into the opening (31), which has had the bottom thereof blocked by the sample (7). During measurement, a probe (106) is lowered so as to pierce the sample (7), and when the probe (106) is raised, the solvent adheres to the sample adhered to the leading end of the probe (106). According to this configuration, it is possible to repeatedly insert the probe at the same position in a state where the sample is fixed, and because a sufficient amount of solvent adheres to the sample, sufficient ionization is achieved.
Inventors:
MURATA TASUKU (JP)
UCHIDA TAKESHI (JP)
OGATA KORETSUGU (JP)
UCHIDA TAKESHI (JP)
OGATA KORETSUGU (JP)
Application Number:
PCT/JP2017/020253
Publication Date:
December 06, 2018
Filing Date:
May 31, 2017
Export Citation:
Assignee:
SHIMADZU CORP (JP)
International Classes:
G01N27/62; H01J49/04
Domestic Patent References:
| WO2004051228A1 | 2004-06-17 | |||
| WO2016027319A1 | 2016-02-25 | |||
| WO2016027319A1 | 2016-02-25 |
Foreign References:
| JP2002515820A | 2002-05-28 | |||
| US5716825A | 1998-02-10 | |||
| JPH07260646A | 1995-10-13 | |||
| JP2012233707A | 2012-11-29 | |||
| JP2014044110A | 2014-03-13 | |||
| JP2014044110A | 2014-03-13 |
Other References:
MRIDUL KANTI MANDAL ET AL.: "Detection of protein from detergent solutions by probe electrospray ionization mass spectrometry (PESI‐MS)", JOURNAL OF MASS SPECTROMETRY, vol. 46, no. 10, 28 September 2011 (2011-09-28), pages 967 - 975, XP055634269, DOI: 10.1002/jms.1977
ZAITSU, K. ET AL.: "Intact Endogenous Metabolite Analysis of Mice Liver by Probe Electrospray Ionization/Triple Quadrupole Tandem Mass Spectrometry and Its Preliminary Application to in Vivo Real-Time Analysis", ANALYTICAL CHEMISTRY, vol. 88, no. 7, 9 March 2016 (2016-03-09), pages 3556 - 3561, XP055422081, DOI: 10.1021/acs.analchem.5b04046
SEN TAKEDA: "Developing a Novel Cancer Diagnostic System Based on the Mass Spectrometry and Learning Machine", SHIMADZU REVIEW, vol. 69, no. 3/4, March 2013 (2013-03-01)
See also references of EP 3633365A4
ZAITSU, K. ET AL.: "Intact Endogenous Metabolite Analysis of Mice Liver by Probe Electrospray Ionization/Triple Quadrupole Tandem Mass Spectrometry and Its Preliminary Application to in Vivo Real-Time Analysis", ANALYTICAL CHEMISTRY, vol. 88, no. 7, 9 March 2016 (2016-03-09), pages 3556 - 3561, XP055422081, DOI: 10.1021/acs.analchem.5b04046
SEN TAKEDA: "Developing a Novel Cancer Diagnostic System Based on the Mass Spectrometry and Learning Machine", SHIMADZU REVIEW, vol. 69, no. 3/4, March 2013 (2013-03-01)
See also references of EP 3633365A4
Attorney, Agent or Firm:
KYOTO INTERNATIONAL PATENT LAW OFFICE (JP)
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