Title:
SAMPLING PROBE MICROARRAY READ OUT USING ELECTROSPRAY MASS SPECTROMETRY
Document Type and Number:
WIPO Patent Application WO2003090249
Kind Code:
A3
Abstract:
An automated electrospray based sampling system and method for analysis obtains samples from surface array spots having analytes. The system includes at least one probe, the probe including an inlet for flowing at least one eluting solvent to respective ones of a plurality of spots and an outlet for directing the analyte away from the spots. An automatic positioning system is provided for translating the probe relative to the spots to permit sampling of any spot. An electrospray ion source having an input fluidicly connected to the probe receives the analyte and generates ions from the analyte. The ion source provides the generated ions to a structure for analysis to identify the analyte, preferably being a mass spectrometer. The probe can be a surface contact probe, where the probe forms an enclosing seal along the periphery of the array spot surface.
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Inventors:
VAN BERKEL GARY J
Application Number:
PCT/US2003/010835
Publication Date:
February 12, 2004
Filing Date:
April 09, 2003
Export Citation:
Assignee:
UT BATELLE LLC (US)
International Classes:
G01N1/00; G01N33/53; G01N27/62; G01N37/00; G01Q60/60; G01Q80/00; H01J49/04; H01J49/26; G01N35/00; (IPC1-7): H01J49/04; G01N35/00
Foreign References:
| US20020011562A1 | 2002-01-31 |
Other References:
"High-Thoughput Microfabricted CE/ESI-MS: Automated sampling from a Microwell Plate.", ANALYTICAL CHEMISTRY., vol. 73, no. 11, 1 June 2001 (2001-06-01), AMERICAN CHEMICAL SOCIETY. COLUMBUS., US, pages 2675 - 2681, XP002257092, ISSN: 0003-2700
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