Title:
SANDWICH AND SPECIES-SPECIFIC NUCLEIC ACID APTAMERS AGAINST PLASMODIUM LACTATE DEHYDROGENASE FOR MALARIA DIAGNOSIS
Document Type and Number:
WIPO Patent Application WO/2019/113827
Kind Code:
A1
Abstract:
Disclosed are aptamers, referred to as pLDH aptamers, that specifically bind to both Plasmodium falciparum lactate dehydrogenase (PfLDH) and Plasmodium vivax lactate dehydrogenase (PvLDH), which are diagnostic markers for malaria and also play a pivotal role in Plasmodium parasite metabolism. The pLDH aptamers can be used to detect Plasmodium, detect or diagnose Plasmodium infection, detect or diagnose malaria, distinguish whether a Plasmodium infection is caused by Plasmodium falciparum or Plasmodium vivax, monitoring the treatment of or progression of a Plasmodium infection, and grading the severity of malaria in a subject. The pLDH aptamers can also be used for prophylactic and therapeutic effect in Plasmodium infections.
Inventors:
TANNER JULIAN ALEXANDER (CN)
CHEUNG YEE WAI (CN)
CHEUNG YEE WAI (CN)
Application Number:
PCT/CN2017/115895
Publication Date:
June 20, 2019
Filing Date:
December 13, 2017
Export Citation:
Assignee:
VERSITECH LTD (CN)
International Classes:
C12N15/115; C12Q1/6893
Foreign References:
| CN104245957A | 2014-12-24 | |||
| CN102816763A | 2012-12-12 |
Attorney, Agent or Firm:
CHINA PATENT AGENT (H.K.) LTD. (CN)
Download PDF:
Previous Patent: CAMSHAFT PHASER
Next Patent: METHOD AND APPARATUS FOR ESTIMATING REMAINING MILEAGE OF PURE ELECTRIC VEHICLE
Next Patent: METHOD AND APPARATUS FOR ESTIMATING REMAINING MILEAGE OF PURE ELECTRIC VEHICLE