Title:
SAPONINS, THE PREPARATION AND THE USE OF THE SAME
Document Type and Number:
WIPO Patent Application WO/2005/095438
Kind Code:
A1
Abstract:
The present invention relates to steroidal saponins, the preparation thereof, and the use of the same in prevention of cardio-vascular diseases of myocardial infarction or the like. The chemical formula of such steroidal saponins is the following general formula (I) or (II). In the invention, such steroidal saponins of formula (I) or (II) can be isolated from traditional Chinese medicines and natural products by several methods of isolation, or be obtained by synthesis and semi-synthesis. The oral or non-oral formulations can be formulated by conventional methods using single compound or the mixture of such compounds in the different proportion. Such formulations can be used for prevention of many cardio-vascular diseases of myocardial infarction, coronary heart disease, angina pectoris, arrhythmia, myocardial ischemia, hypertension, hyperlipidemia and blood viscous or the like. In the general formula (I) or (II), R1=ß-D-glucose; R2 linear sugar chain or branched sugar chain; R3=H or CH3.
Inventors:
YAO XINSHENG (CN)
LI LIANDA (CN)
WANG NAILI (CN)
ZHANG RONGLI (CN)
CHEN HAIFENG (CN)
SHEN PING (CN)
QU GEXIA (CN)
LI LIANDA (CN)
WANG NAILI (CN)
ZHANG RONGLI (CN)
CHEN HAIFENG (CN)
SHEN PING (CN)
QU GEXIA (CN)
Application Number:
PCT/CN2005/000364
Publication Date:
October 13, 2005
Filing Date:
March 22, 2005
Export Citation:
Assignee:
SHENZHEN RES CT OF TRADITIONAL (CN)
YAO XINSHENG (CN)
LI LIANDA (CN)
WANG NAILI (CN)
ZHANG RONGLI (CN)
CHEN HAIFENG (CN)
SHEN PING (CN)
QU GEXIA (CN)
YAO XINSHENG (CN)
LI LIANDA (CN)
WANG NAILI (CN)
ZHANG RONGLI (CN)
CHEN HAIFENG (CN)
SHEN PING (CN)
QU GEXIA (CN)
International Classes:
A61K31/7048; A61P3/06; A61P9/10; A61P9/12; C07J71/00; (IPC1-7): C07J71/00; A61K31/7048; A61P3/06; A61P9/10; A61P9/12
Foreign References:
| CN1415625A | 2003-05-07 |
Other References:
XUEJUN S. ET AL: "Chemical constituents of rhizome of sheath-stipe greenbrier (Smilax stans).", ZHONGCAOYAO., vol. 26, no. 8, 1995, pages 395 - 399
ZHANG JIAN-BO ET AL: "Recent progress in research of furostanol saponins.", YOUJI HUAXUE., vol. 20, no. 5, 2000, pages 663 - 688
ZHANG JIAN-BO ET AL: "Recent progress in research of furostanol saponins.", YOUJI HUAXUE., vol. 20, no. 5, 2000, pages 663 - 688
Attorney, Agent or Firm:
SHENZHEN STANDARD PATENT & TRADEMARK AGENT LTD. (Yinzuo Int'l Building No. 1056 Shennan Boulevar, Shenzhen Guangdong 0, CN)
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