Title:
SARS-COV-2-FIGHTING HUMANIZED MULTIVALENT BINDING PROTEIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/246853
Kind Code:
A1
Abstract:
The present invention relates to the technical field of antibodies, and specifically relates to a SARS-CoV-2-fighting humanized multivalent binding protein and a use thereof. The multivalent binding protein can effectively block the binding of RBD proteins of wild-type SARS-CoV-2 and the Delta and Omicron variants of SARS-CoV-2 with human ACE2 receptor proteins; compared with monovalent binding proteins, the present multivalent binding protein has more prominent SARS-CoV-2 neutralizing activity and can be widely used in SARS-COV-2 prevention and treatment.
Inventors:
LU DI (CN)
HUO YONGTING (CN)
HUO YONGTING (CN)
Application Number:
PCT/CN2023/101644
Publication Date:
December 28, 2023
Filing Date:
June 21, 2023
Export Citation:
Assignee:
GUANGDONG FAPON BIOPHARMA INC (CN)
International Classes:
C07K16/46; A61K39/42; A61P31/14; C07K16/10; C07K19/00; C12N15/13; C12N15/62; C12P21/02
Domestic Patent References:
| WO2021170113A1 | 2021-09-02 | |||
| WO2022032660A1 | 2022-02-17 |
Foreign References:
| CN115057938A | 2022-09-16 | |||
| CN111358943A | 2020-07-03 | |||
| CN113018427A | 2021-06-25 | |||
| CN112707968A | 2021-04-27 | |||
| CN114106162A | 2022-03-01 | |||
| CN114349851A | 2022-04-15 |
Other References:
DATABASE Protein 8 March 2021 (2021-03-08), ANONYMOUS : "immunoglobulin heavy chain variable region, partial [Homo sapiens]", XP093120633, retrieved from NCBI Database accession no. QSI98620
DATABASE Protein 5 October 2022 (2022-10-05), ANONYMOUS : "Chain E, Nanobody B5 ", XP093120645, retrieved from NCBI Database accession no. 7Z1C_E
BAO-AN YANG, YANG YIN-HUI, LI JIA-MING, LV FU-SHUANG, LIU HONG, CHANG GUO-HUI,: "Screening and epitope mapping of monoclonal antibodies to severe acute respiratory syndrome-associated coronavirus", CHINESE JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY, vol. 26, no. 3, 30 March 2006 (2006-03-30), pages 215 - 219, XP093120643
DATABASE Protein 5 October 2022 (2022-10-05), ANONYMOUS : "Chain E, Nanobody B5 ", XP093120645, retrieved from NCBI Database accession no. 7Z1C_E
BAO-AN YANG, YANG YIN-HUI, LI JIA-MING, LV FU-SHUANG, LIU HONG, CHANG GUO-HUI,: "Screening and epitope mapping of monoclonal antibodies to severe acute respiratory syndrome-associated coronavirus", CHINESE JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY, vol. 26, no. 3, 30 March 2006 (2006-03-30), pages 215 - 219, XP093120643
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (CN)
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