Title:
SCAFFOLD-FREE SELF-ORGANIZING THREE-DIMENSIONAL ARTIFICIAL TISSUE AND ARTIFICIAL BONE COMPOSITE FOR OSTEOCHONDRAL REGENERATION
Document Type and Number:
WIPO Patent Application WO/2013/099273
Kind Code:
A1
Abstract:
[Problem] To provide a method of therapy in which osteochondral damage is mitigated. [Solution] To treat or prevent a disease, disorder, or condition related to osteochondral defect, a composite tissue that includes a three-dimensional artificial tissue and artificial bone, wherein the three-dimensional artificial tissue is substantially constituted of cells and the extracellular matrix derived from the cells, and the extracellular matrix comprises fibronectin, collagen I, collagen III, and vitronectin, the extracellular matrix being arranged dispersed within the tissue.
Inventors:
YOSHIKAWA HIDEKI (JP)
NAKAMURA NORIMASA (JP)
SHIMOMURA KAZUNORI (JP)
MORIGUCHI YU (JP)
NAKAMURA NORIMASA (JP)
SHIMOMURA KAZUNORI (JP)
MORIGUCHI YU (JP)
Application Number:
PCT/JP2012/008410
Publication Date:
July 04, 2013
Filing Date:
December 27, 2012
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
A61L27/00; A61F2/28
Domestic Patent References:
| WO2000051527A1 | 2000-09-08 | |||
| WO2003024463A1 | 2003-03-27 |
Foreign References:
| JP4522994B2 | 2010-08-11 | |||
| JP4522994B2 | 2010-08-11 | |||
| JP2001137328A | 2001-05-22 | |||
| JP2008126005A | 2008-06-05 | |||
| JPS5111383A | 1976-01-29 |
Other References:
BIOMATERIALS, vol. 27, 2006, pages 4120 - 4131, XP005402075
TISSUE ENGINEERING, vol. 11, no. 1/2, 2005, pages 331 - 339, XP055076542
See also references of EP 2799093A4
HARRIS ED, JR., ARTHRITIS RHEUM, vol. 44, 2001, pages 1969 - 1970
GOMOLL AH; MADRY H; KNUTSEN G; VAN DIJKN; SEIL R; BRITTBERG M ET AL., KNEE SURG SPORTS TRAUMATOL ARTHROSC, vol. 18, 2010, pages 434 - 447
KON E; DELCOGLIANO M; FILARDO G; BUSACCA M; DI MARTINO A; MARCACCI M., AM J SPORTS MED, vol. 39, 2011, pages 1180 - 1190
HUNG CT; LIMA EG; MAUCK RL; TAKAI E; LEROUX MA; LU HH ET AL., J BIOMECH, vol. 36, 2003, pages 1853 - 1864
MARQUASS B; SOMERSON JS; HEPP P; AIGNER T; SCHWAN S; BADER A ET AL., J ORTHOP RES, vol. 28, 2010, pages 1586 - 1599
OLIVEIRA JM; RODRIGUES MT; SILVA SS; MALAFAYA PB; GOMES ME; VIEGAS CA ET AL., BIOMATERIALS, vol. 27, 2006, pages 6123 - 6137
SHERWOOD JK; RILEY SL; PALAZZOLO R; BROWN SC; MONKHOUSE DC; COATES M ET AL., BIOMATERIALS, vol. 23, 2002, pages 4739 - 4751
AHN JH; LEE TH; OH JS; KIM SY; KIM HJ; PARK IK ET AL., TISSUE ENG PART A, vol. 15, 2009, pages 2595 - 2604
ALHADLAQ A; MAO JJ., J BONE JOINT SURG AM, vol. 87, 2005, pages 936 - 944
GAO J; DENNIS JE; SOLCHAGA LA; GOLDBERG VM; CAPLANAI., TISSUE ENG, vol. 8, 2002, pages 827 - 837
KANDEL RA; GRYNPAS M; PILLIAR R; LEE J; WANG J; WALDMAN S ET AL., BIOMATERIALS, vol. 27, 2006, pages 4120 - 413
CHEN J; CHEN H; LI P; DIAO H; ZHU S; DONG L ET AL., BIOMATERIALS, vol. 32, 2011, pages 4793 - 4805
TAMAI N; MYOUI A; HIRAO M; KAITO T; OCHI T; TANAKA J ET AL., OSTEOARTHRITIS CARTILAGE, vol. 13, 2005, pages 405 - 417
TAMAI N; MYOUI A; KUDAWARA I; UEDA T; YOSHIKAWA H., J ORTHOP SCI, vol. 15, 2010, pages 560 - 568
SHEN C; MA J; CHEN XD; DAI LY., KNEE SURG SPORTS TRAUMATOL ARTHROSC, vol. 17, 2009, pages 1406 - 1411
ANDO W; TATEISHI K; KATAKAI D; HART DA; HIGUCHI C; NAKATA K ET AL., TISSUE ENG PART A, vol. 14, 2008, pages 2041 - 2049
ANDO W; TATEISHI K; HART DA; KATAKAI D; TANAKA Y; NAKATA K ET AL., BIOMATERIALS, vol. 28, 2007, pages 5462 - 5470
SHIMOMURA K; ANDO W; TATEISHI K; NANSAI R; FUJIE H; HART DA ET AL., BIOMATERIALS, vol. 31, 2010, pages 8004 - 8011
JANKOWISKI RJ; HUAND J ET AL., GENE, vol. 9, 2002, pages 642 - 647
WICKHAM MQ ET AL., CLIN.ORTHOP., vol. 412, 2003, pages 196 - 212
LEE OK ET AL., BLOOD, vol. 103, 2004, pages 1669 - 75
SALINGCARNBORIBOONR., EXP.CELL.RES., vol. 287, 2002, pages 289 - 300
PITTERGER MF ET AL., SCIENCE, vol. 284, 1999, pages 143 - 147
DE BARI C; DELL'ACCIO F; TYLZANOWSKI P; LUYTEN FP, ARTHRITIS RHEUM., vol. 44, 2001, pages 1928 - 42
OKANO T; YAMADA N; SAKAI H; SAKURAI Y., J BIOMED MATER RES., vol. 27, 1993, pages 1243 - 1251
KUSHIDA A; YAMATO M; KONNO C; KIKUCHI A; SAKURAI Y; OKANO T., J BIOMED. MATER. RES., vol. 45, 1999, pages 355 - 362
SHIMIZU T; YAMATO M; AKUTSU T ET AL., CIRC RES., vol. 90, no. 3, 22 February 2002 (2002-02-22), pages E40
TAMAI N ET AL., OSTEOARTHRITIS CARTILAGE, vol. 13, no. 5, 2005, pages 405 - 417
DE PEPPO ET AL., TISSUE ENGINEERING: PART A, vol. 16, 2010, pages 3413 - 3426
TOH ET AL., STEM CELL REV. AND REP., vol. 7, 2011, pages 544 - 559
VARGA ET AL., BIOCHEM.BIOPHYS.RES.COMMUN., 2011
BARBET ET AL., STEM CELLS INTERNATIONAL, 2011
SANCHEZ ET AL., STEM CELLS, vol. 2, 2011, pages 25 - 262
SIMPSON ET AL., BIOTECHNOL.BIOENG., 2011
JUNG ET AL., STEM CELLS, 2011
SANCHEZ ET AL., STEM CELLS, vol. 29, 2011, pages 51 - 62
MPSON ET AL., ECHNOL. IOENG., 2011
"Hito Ishoku Zoki Kyozetsu Hanno no Byori Soshiki Shindan Kij yun Kanbetsu Shindan to Seiken Hyohon no Toriatsukai (Zufu) Jinzo Ishoku, Kanzo Ishoku Oyobi Shinzo Ishoku", 1998, KANEHARA SHUPPAN KABUSHIKI KAISHA
"Saibokokkaku/Undo ga wakaru", YODO-SHA
TAKENAKA T ET AL., J.CELL SCI., vol. 114, 2001, pages 1801 - 1809
"Shin Gekagaku Taikei, Dai 12 Kan, Zoki Ishoku (Shinzo Ishoku - Hai Ishoku Gijutsuteki, Rinriteki Seibi kara Jisshi ni Mukete", vol. 12, NAKAYAMA SHOTEN
KULYK WM; FRANKLIN JL; HOFFMAN LM.: "Sox9 expression during chondrogenesis in micromass cultures of embryonic limb mesenchyme", EXP CELL RES., vol. 255, no. 2, 15 March 2000 (2000-03-15), pages 327 - 32
HAASE HR; IVANOVSKI S; WATERS MJ; BARTOLD PM.: "Growth hormone regulates osteogenic marker mRNA expression in human periodontal fibroblasts and alveolar bone-derived cells", J PERIODONTAL RES., vol. 38, no. 4, August 2003 (2003-08-01), pages 366 - 74
WOLFMAN NM; HATTERSLEY G; COX K; CELESTE AJ; NELSON R; YAMAJ IN; DUBE JL; DIBLASIO-SMITH E; NOVE J; SONG JJ: "Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family", J CLIN INVEST., vol. 100, no. 2, 15 July 1997 (1997-07-15), pages 321 - 30
DREYER SD; NARUSE T; MORELLO R; ZABEL B; WINTERPACHT A; JOHNSON RL; LEE B; OBERG KC.: "Lmxlb expression during joint and tendon formation: localization and evaluation of potential downstream targets", GENE EXPR PATTERNS, vol. 4, no. 4, July 2004 (2004-07-01), pages 397 - 405
BRENT AE; SCHWEITZER R; TABIN CJ.: "A somitic compartment of tendon progenitors", CELL, vol. 113, no. 2, 18 April 2003 (2003-04-18), pages 235 - 48
HUNZIKER E.B. ET AL., J. BONE JOINT SURG. AM., vol. 78, no. 5, May 1996 (1996-05-01), pages 721 - 33
F. BERENBAUM: "The OARSI histopathology initiative - the tasks and limitations", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages S1
TRATTNIG S; WINALSKI CS; MARLOVITS S; JURVELIN JS; WELSCH GH; POTTER HG.: "Magnetic resonance imaging of cartilage repair: a review", CARTILAGE, vol. 2, 2011, pages 5 - 26
MITHOEFER K; SARIS DBF; FARR J; KON E; ZASLAV K; COLE B; RANSTAM J; YAO J; SHIVE MS; BRITTBERG M.: "Guidelines for the design and conduct of clinical studies in knee articular cartilage repair: International Cartilage Repair Society recommendations based on current scientific evidence and standards of clinical care", CARTILAGE, vol. 2, 2011, pages 100 - 121
ROOS EM; ENGELHART L; RANSTAM J; ANDERSON AF; IRRGANG JJ; MARX R; TEGNER Y; DAVIS AM.: "Patient-reported outcome instruments for use in patients with articular cartilage injuries", CARTILAGE, vol. 2, 2011, pages 122 - 136
HURTIG M; BUSCHMANN MD; FORTIER L; HOEMANN CD; HUNZIKER EB; JURVELIN JS; MAINIL-VARLET P; MCILWRAITH W; SAH RL; WHITESIDE RA.: "Preclinical studies for cartilage repair: recommendations from the International Cartilage Repair Society", CARTILAGE, vol. 2, 2011, pages 137 - 153
HOEMANN CD; KANDEL R; ROBERTS S; SARIS D; CREEMERS L; MANIL-VARLET P; METHOT S; HOLLANDER A; BUSCHMANN MD.: "Recommended guidelines for histological endpoints for cartilage repair studies in animal models and clinical trials", CARTILAGE, vol. 2, 2011, pages 154 - 173
C. WAYNE MCILWRAITH; DAVID D. FRISBIE: "Microfracture: Basic Science Studies in the Horse", CARTILAGE, vol. 1, 2010, pages 87 - 95
T. AIGNER; J.L. COOK; N. GERWIN X; S.S. GLASSON K; S. LAVERTY; C.B. LITTLE; W. MCILWRAITH; V.B. KRAUS: "Histopathology atlas of animal model systems e overview of guiding principles", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages S2 - S6
K.P.H. PRITZKER; T. AIGNER: "Terminology of osteoarthritis cartilage and bone histopathology - a proposal for a consensus", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages S7 - S9
R. POOLE; S. BLAKE; M. BUSCHMANN; S. GOLDRING; S. LAVERTY; S. LOCKWOOD; J. MATYAS; J. MCDOUGALL; K. PRITZKER; K. RUDOLPHI: "Recommendations for the use of preclinical models in the study and treatment of osteoarthritis", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages S10 - S16
S.S. GLASSON; M.G. CHAMBERS; W.B. VAN DEN BERG; C.B. LITTLE: "The OARSI histopathology initiative e recommendations for histological assessments of osteoarthritis in the mouse", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages S17 - S23
N. GERWIN; A.M. BENDELE; S. GLASSON; C.S. CARLSON: "The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the rat", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages S24 - S34
V.B. KRAUS; J.L. HUEBNER; J. DEGROOT; A. BENDELE: "The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the guinea pig", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages S35 - S52
S. LAVERTY; C.A. GIRARD; J.M. WILLIAMS; E.B. HUNZIKER; K.P.H. PRITZKER: "The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the rabbit", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages S53 - S65
J.L. COOK; K. KUROKI; D. VISCO; J.-P. PELLETIER; L. SCHULZ; F.P.J.G LAFEBER: "The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the dog", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages S66 - S79
C.B. LITTLE; M.M. SMITH; M.A. CAKE; R.A. READ; M.J. MURPHY; F.P. BARRY: "The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in sheep and goats", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages S80 - S92
C.W. MCILWRAITH; D.D. FRISBIE; C.E. KAWCAK; C.J. FULLER; M. HURTIG; A. CRUZ: "The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the horse", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages S93 - S105
P.CPASTOUREAU; E.BHUNZIKER; J.-P. PELLETIER: "Cartilage, bone and synovial histomorphometry in animal models of osteoarthritis", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages S106 - S112
N. SCHMITZ; S. LAVERTY; V.B. KRAUS; T. AIGNER: "Basic methods in histopathology of joint tissues", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages 5113 - 5116
G.L. PEARCE; D.D. FRISBIE: "Statistical evaluationofbiomedical studies", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages S117 - SL22
0' DRISCOLL SW; KEELEY FW; SALTER RB., J BONE JOINT SURG AM, vol. 70, 1988, pages 595 - 606
MROSEK EH; SCHAGEMANN JC; CHUNG HW; FITZSIMMONS JS; YASZEMSKI MJ; MARDONES RM ET AL., J ORTHOP RES, vol. 28, 2010, pages 141 - 148
OLIVOS-MEZA A; FITZSIMMONS JS; CASPER ME; CHEN Q; AN KN; RUESINK TJ ET AL., OSTEOARTHRITIS CARTILAGE, vol. 18, 2010, pages 118 3 - 1191
HATA R.; SENOO H., J. CELL PHYSIOL., vol. 138, no. 1, 1989, pages 8 - 16
NATURE, vol. 342, 1989, pages 440
BIOCHEM-BIOPHYS. RES. COMMUN., vol. 163, 1989, pages 967
MOLECULAR MEDICINE, vol. 30, 1993, pages 1440 - 1448
JIKKEN IGAKU, vol. 12, 1994, pages 1822 - 1826
TATEISHI K; HIGUCHI C; ANDO W; NAKATA K; HASHIMOTO J; HART DA ET AL., OSTEOARTHRITIS CARTILAGE, vol. 15, 2007, pages 709 - 718
O'DRISCOLL SW; KEELEY FW; SALTER RB., J BONE JOINT SURG AM, vol. 70, 1988, pages 595 - 606
OLIVOS-MEZA A; FITZSIMMONS JS; CASPER ME; CHEN Q; AN KN; RUESINK TJ ET AL., OSTEOARTHRITIS CARTILAGE, vol. 18, 2010, pages 1183 - 1191
SHERWOOD JK; RILEY SL; PALAZZOLO R; BROWN SC; MONKHOUSE DC; COATESM ET AL., BIOMATERIALS, vol. 23, 2002, pages 4739 - 4751
ALHADLAQ A; MAO JJ., J BONE JOINT SURGAM, vol. 87, 2005, pages 936 - 944
GAOJ; DENNIS JE; SOLCHAGALA; GOLDBERG VM; CAPLANAI., TISSUE ENG, vol. 8, 2002, pages 827 - 837
KANDEL RA; GRYNPAS M; PILLIAR R; LEE J; WANG J; WALDMAN S ET AL., BIOMATERIALS, vol. 27, 2006, pages 4120 - 4131
KON E; GOBBI A; FILARDO G; DELCOGLIANO M; ZAFFAGNINI S; MARCACCI M., AM J SPORTS MED, vol. 37, 2009, pages 33 - 41
BASAD E; ISHAQUE B; BACHMANN G; STURZ H; STEINMEYER J., KNEE SURG SPORTS TRAUMATOL ARTHROSC, vol. 18, 2010, pages 519 - 527
SHEN C, MA J; CHEN XD; DAI LY., KNEE SURG SPORTS TRAUMATOL ARTHROSC, vol. 17, 2009, pages 1406 - 1411
GOMOLLAH; MADRYH; KNUTSENG; VANDIJKN; SEILR; BRITTBERG M ET AL., KNEE SURG SPORTS TRAUMATOL ARTHROSC, vol. 18, 2010, pages 434 - 447
KONE; DELCOGLIANO M; FILARDO G; BUSACCA M; DI MARTINO A; MARCACCI M., AM J SPORTS MED, vol. 39, 2011, pages 1180 - 1190
MINAS T; GOMOLL AH; ROSENBERGER R; ROYCE RO; BRYANT T., AM J SPORTS MED, vol. 37, 2009, pages 902 - 908
WAKITANI S; GOTO T; PINEDA SJ; YOUNG RG; MANSOUR JM; CAPLAN AI ET AL., JBONE JOINT SURG AM, vol. 76, 1994, pages 579 - 592
CHEN H; CHEVRIER A; HOEMANN CD; SUN J; OUYANG W; BUSCHMANN MD., AM J SPORTS MED, 2011
BEDI A; FEELEY BT; WILLIAMS RJ, 3RD., J BONE JOINT SURG AM, vol. 92, 2010, pages 994 - 1009
VASARA AI; HYTTINENMM; LAMMI MJ; LAMMI PE; LANGSJO TK; LINDAHL A ET AL., CALCIF TISSUE INT, vol. 74, 2004, pages 107 - 114
LIU G; KAWAGUCHI H; OGASAWARA T; ASAWA Y; KISHIMOTO J; TAKAHASHI T ET AL., J BIOL CHEM, vol. 282, 2007, pages 20407 - 20415
ANDOW; TATEISHI K; KATAKAI D; HART DA; HIGUCHI C; NAKATA K ET AL., TISSUE ENG PART A, vol. 14, 2008, pages 2041 - 2049
TISSUE ENGINEERING: PART A, vol. 6, 2010, pages 3413 - 3426
SANCHEZ ET AL., STEM CELLS, vol. 29, 2011, pages 251 - 262
TISSUE ENGINEERING, vol. 11, no. 1/2, 2005, pages 331 - 339, XP055076542
See also references of EP 2799093A4
HARRIS ED, JR., ARTHRITIS RHEUM, vol. 44, 2001, pages 1969 - 1970
GOMOLL AH; MADRY H; KNUTSEN G; VAN DIJKN; SEIL R; BRITTBERG M ET AL., KNEE SURG SPORTS TRAUMATOL ARTHROSC, vol. 18, 2010, pages 434 - 447
KON E; DELCOGLIANO M; FILARDO G; BUSACCA M; DI MARTINO A; MARCACCI M., AM J SPORTS MED, vol. 39, 2011, pages 1180 - 1190
HUNG CT; LIMA EG; MAUCK RL; TAKAI E; LEROUX MA; LU HH ET AL., J BIOMECH, vol. 36, 2003, pages 1853 - 1864
MARQUASS B; SOMERSON JS; HEPP P; AIGNER T; SCHWAN S; BADER A ET AL., J ORTHOP RES, vol. 28, 2010, pages 1586 - 1599
OLIVEIRA JM; RODRIGUES MT; SILVA SS; MALAFAYA PB; GOMES ME; VIEGAS CA ET AL., BIOMATERIALS, vol. 27, 2006, pages 6123 - 6137
SHERWOOD JK; RILEY SL; PALAZZOLO R; BROWN SC; MONKHOUSE DC; COATES M ET AL., BIOMATERIALS, vol. 23, 2002, pages 4739 - 4751
AHN JH; LEE TH; OH JS; KIM SY; KIM HJ; PARK IK ET AL., TISSUE ENG PART A, vol. 15, 2009, pages 2595 - 2604
ALHADLAQ A; MAO JJ., J BONE JOINT SURG AM, vol. 87, 2005, pages 936 - 944
GAO J; DENNIS JE; SOLCHAGA LA; GOLDBERG VM; CAPLANAI., TISSUE ENG, vol. 8, 2002, pages 827 - 837
KANDEL RA; GRYNPAS M; PILLIAR R; LEE J; WANG J; WALDMAN S ET AL., BIOMATERIALS, vol. 27, 2006, pages 4120 - 413
CHEN J; CHEN H; LI P; DIAO H; ZHU S; DONG L ET AL., BIOMATERIALS, vol. 32, 2011, pages 4793 - 4805
TAMAI N; MYOUI A; HIRAO M; KAITO T; OCHI T; TANAKA J ET AL., OSTEOARTHRITIS CARTILAGE, vol. 13, 2005, pages 405 - 417
TAMAI N; MYOUI A; KUDAWARA I; UEDA T; YOSHIKAWA H., J ORTHOP SCI, vol. 15, 2010, pages 560 - 568
SHEN C; MA J; CHEN XD; DAI LY., KNEE SURG SPORTS TRAUMATOL ARTHROSC, vol. 17, 2009, pages 1406 - 1411
ANDO W; TATEISHI K; KATAKAI D; HART DA; HIGUCHI C; NAKATA K ET AL., TISSUE ENG PART A, vol. 14, 2008, pages 2041 - 2049
ANDO W; TATEISHI K; HART DA; KATAKAI D; TANAKA Y; NAKATA K ET AL., BIOMATERIALS, vol. 28, 2007, pages 5462 - 5470
SHIMOMURA K; ANDO W; TATEISHI K; NANSAI R; FUJIE H; HART DA ET AL., BIOMATERIALS, vol. 31, 2010, pages 8004 - 8011
JANKOWISKI RJ; HUAND J ET AL., GENE, vol. 9, 2002, pages 642 - 647
WICKHAM MQ ET AL., CLIN.ORTHOP., vol. 412, 2003, pages 196 - 212
LEE OK ET AL., BLOOD, vol. 103, 2004, pages 1669 - 75
SALINGCARNBORIBOONR., EXP.CELL.RES., vol. 287, 2002, pages 289 - 300
PITTERGER MF ET AL., SCIENCE, vol. 284, 1999, pages 143 - 147
DE BARI C; DELL'ACCIO F; TYLZANOWSKI P; LUYTEN FP, ARTHRITIS RHEUM., vol. 44, 2001, pages 1928 - 42
OKANO T; YAMADA N; SAKAI H; SAKURAI Y., J BIOMED MATER RES., vol. 27, 1993, pages 1243 - 1251
KUSHIDA A; YAMATO M; KONNO C; KIKUCHI A; SAKURAI Y; OKANO T., J BIOMED. MATER. RES., vol. 45, 1999, pages 355 - 362
SHIMIZU T; YAMATO M; AKUTSU T ET AL., CIRC RES., vol. 90, no. 3, 22 February 2002 (2002-02-22), pages E40
TAMAI N ET AL., OSTEOARTHRITIS CARTILAGE, vol. 13, no. 5, 2005, pages 405 - 417
DE PEPPO ET AL., TISSUE ENGINEERING: PART A, vol. 16, 2010, pages 3413 - 3426
TOH ET AL., STEM CELL REV. AND REP., vol. 7, 2011, pages 544 - 559
VARGA ET AL., BIOCHEM.BIOPHYS.RES.COMMUN., 2011
BARBET ET AL., STEM CELLS INTERNATIONAL, 2011
SANCHEZ ET AL., STEM CELLS, vol. 2, 2011, pages 25 - 262
SIMPSON ET AL., BIOTECHNOL.BIOENG., 2011
JUNG ET AL., STEM CELLS, 2011
SANCHEZ ET AL., STEM CELLS, vol. 29, 2011, pages 51 - 62
MPSON ET AL., ECHNOL. IOENG., 2011
"Hito Ishoku Zoki Kyozetsu Hanno no Byori Soshiki Shindan Kij yun Kanbetsu Shindan to Seiken Hyohon no Toriatsukai (Zufu) Jinzo Ishoku, Kanzo Ishoku Oyobi Shinzo Ishoku", 1998, KANEHARA SHUPPAN KABUSHIKI KAISHA
"Saibokokkaku/Undo ga wakaru", YODO-SHA
TAKENAKA T ET AL., J.CELL SCI., vol. 114, 2001, pages 1801 - 1809
"Shin Gekagaku Taikei, Dai 12 Kan, Zoki Ishoku (Shinzo Ishoku - Hai Ishoku Gijutsuteki, Rinriteki Seibi kara Jisshi ni Mukete", vol. 12, NAKAYAMA SHOTEN
KULYK WM; FRANKLIN JL; HOFFMAN LM.: "Sox9 expression during chondrogenesis in micromass cultures of embryonic limb mesenchyme", EXP CELL RES., vol. 255, no. 2, 15 March 2000 (2000-03-15), pages 327 - 32
HAASE HR; IVANOVSKI S; WATERS MJ; BARTOLD PM.: "Growth hormone regulates osteogenic marker mRNA expression in human periodontal fibroblasts and alveolar bone-derived cells", J PERIODONTAL RES., vol. 38, no. 4, August 2003 (2003-08-01), pages 366 - 74
WOLFMAN NM; HATTERSLEY G; COX K; CELESTE AJ; NELSON R; YAMAJ IN; DUBE JL; DIBLASIO-SMITH E; NOVE J; SONG JJ: "Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family", J CLIN INVEST., vol. 100, no. 2, 15 July 1997 (1997-07-15), pages 321 - 30
DREYER SD; NARUSE T; MORELLO R; ZABEL B; WINTERPACHT A; JOHNSON RL; LEE B; OBERG KC.: "Lmxlb expression during joint and tendon formation: localization and evaluation of potential downstream targets", GENE EXPR PATTERNS, vol. 4, no. 4, July 2004 (2004-07-01), pages 397 - 405
BRENT AE; SCHWEITZER R; TABIN CJ.: "A somitic compartment of tendon progenitors", CELL, vol. 113, no. 2, 18 April 2003 (2003-04-18), pages 235 - 48
HUNZIKER E.B. ET AL., J. BONE JOINT SURG. AM., vol. 78, no. 5, May 1996 (1996-05-01), pages 721 - 33
F. BERENBAUM: "The OARSI histopathology initiative - the tasks and limitations", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages S1
TRATTNIG S; WINALSKI CS; MARLOVITS S; JURVELIN JS; WELSCH GH; POTTER HG.: "Magnetic resonance imaging of cartilage repair: a review", CARTILAGE, vol. 2, 2011, pages 5 - 26
MITHOEFER K; SARIS DBF; FARR J; KON E; ZASLAV K; COLE B; RANSTAM J; YAO J; SHIVE MS; BRITTBERG M.: "Guidelines for the design and conduct of clinical studies in knee articular cartilage repair: International Cartilage Repair Society recommendations based on current scientific evidence and standards of clinical care", CARTILAGE, vol. 2, 2011, pages 100 - 121
ROOS EM; ENGELHART L; RANSTAM J; ANDERSON AF; IRRGANG JJ; MARX R; TEGNER Y; DAVIS AM.: "Patient-reported outcome instruments for use in patients with articular cartilage injuries", CARTILAGE, vol. 2, 2011, pages 122 - 136
HURTIG M; BUSCHMANN MD; FORTIER L; HOEMANN CD; HUNZIKER EB; JURVELIN JS; MAINIL-VARLET P; MCILWRAITH W; SAH RL; WHITESIDE RA.: "Preclinical studies for cartilage repair: recommendations from the International Cartilage Repair Society", CARTILAGE, vol. 2, 2011, pages 137 - 153
HOEMANN CD; KANDEL R; ROBERTS S; SARIS D; CREEMERS L; MANIL-VARLET P; METHOT S; HOLLANDER A; BUSCHMANN MD.: "Recommended guidelines for histological endpoints for cartilage repair studies in animal models and clinical trials", CARTILAGE, vol. 2, 2011, pages 154 - 173
C. WAYNE MCILWRAITH; DAVID D. FRISBIE: "Microfracture: Basic Science Studies in the Horse", CARTILAGE, vol. 1, 2010, pages 87 - 95
T. AIGNER; J.L. COOK; N. GERWIN X; S.S. GLASSON K; S. LAVERTY; C.B. LITTLE; W. MCILWRAITH; V.B. KRAUS: "Histopathology atlas of animal model systems e overview of guiding principles", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages S2 - S6
K.P.H. PRITZKER; T. AIGNER: "Terminology of osteoarthritis cartilage and bone histopathology - a proposal for a consensus", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages S7 - S9
R. POOLE; S. BLAKE; M. BUSCHMANN; S. GOLDRING; S. LAVERTY; S. LOCKWOOD; J. MATYAS; J. MCDOUGALL; K. PRITZKER; K. RUDOLPHI: "Recommendations for the use of preclinical models in the study and treatment of osteoarthritis", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages S10 - S16
S.S. GLASSON; M.G. CHAMBERS; W.B. VAN DEN BERG; C.B. LITTLE: "The OARSI histopathology initiative e recommendations for histological assessments of osteoarthritis in the mouse", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages S17 - S23
N. GERWIN; A.M. BENDELE; S. GLASSON; C.S. CARLSON: "The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the rat", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages S24 - S34
V.B. KRAUS; J.L. HUEBNER; J. DEGROOT; A. BENDELE: "The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the guinea pig", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages S35 - S52
S. LAVERTY; C.A. GIRARD; J.M. WILLIAMS; E.B. HUNZIKER; K.P.H. PRITZKER: "The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the rabbit", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages S53 - S65
J.L. COOK; K. KUROKI; D. VISCO; J.-P. PELLETIER; L. SCHULZ; F.P.J.G LAFEBER: "The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the dog", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages S66 - S79
C.B. LITTLE; M.M. SMITH; M.A. CAKE; R.A. READ; M.J. MURPHY; F.P. BARRY: "The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in sheep and goats", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages S80 - S92
C.W. MCILWRAITH; D.D. FRISBIE; C.E. KAWCAK; C.J. FULLER; M. HURTIG; A. CRUZ: "The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the horse", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages S93 - S105
P.CPASTOUREAU; E.BHUNZIKER; J.-P. PELLETIER: "Cartilage, bone and synovial histomorphometry in animal models of osteoarthritis", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages S106 - S112
N. SCHMITZ; S. LAVERTY; V.B. KRAUS; T. AIGNER: "Basic methods in histopathology of joint tissues", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages 5113 - 5116
G.L. PEARCE; D.D. FRISBIE: "Statistical evaluationofbiomedical studies", OSTEOARTHRITIS AND CARTILAGE, vol. 18, 2010, pages S117 - SL22
0' DRISCOLL SW; KEELEY FW; SALTER RB., J BONE JOINT SURG AM, vol. 70, 1988, pages 595 - 606
MROSEK EH; SCHAGEMANN JC; CHUNG HW; FITZSIMMONS JS; YASZEMSKI MJ; MARDONES RM ET AL., J ORTHOP RES, vol. 28, 2010, pages 141 - 148
OLIVOS-MEZA A; FITZSIMMONS JS; CASPER ME; CHEN Q; AN KN; RUESINK TJ ET AL., OSTEOARTHRITIS CARTILAGE, vol. 18, 2010, pages 118 3 - 1191
HATA R.; SENOO H., J. CELL PHYSIOL., vol. 138, no. 1, 1989, pages 8 - 16
NATURE, vol. 342, 1989, pages 440
BIOCHEM-BIOPHYS. RES. COMMUN., vol. 163, 1989, pages 967
MOLECULAR MEDICINE, vol. 30, 1993, pages 1440 - 1448
JIKKEN IGAKU, vol. 12, 1994, pages 1822 - 1826
TATEISHI K; HIGUCHI C; ANDO W; NAKATA K; HASHIMOTO J; HART DA ET AL., OSTEOARTHRITIS CARTILAGE, vol. 15, 2007, pages 709 - 718
O'DRISCOLL SW; KEELEY FW; SALTER RB., J BONE JOINT SURG AM, vol. 70, 1988, pages 595 - 606
OLIVOS-MEZA A; FITZSIMMONS JS; CASPER ME; CHEN Q; AN KN; RUESINK TJ ET AL., OSTEOARTHRITIS CARTILAGE, vol. 18, 2010, pages 1183 - 1191
SHERWOOD JK; RILEY SL; PALAZZOLO R; BROWN SC; MONKHOUSE DC; COATESM ET AL., BIOMATERIALS, vol. 23, 2002, pages 4739 - 4751
ALHADLAQ A; MAO JJ., J BONE JOINT SURGAM, vol. 87, 2005, pages 936 - 944
GAOJ; DENNIS JE; SOLCHAGALA; GOLDBERG VM; CAPLANAI., TISSUE ENG, vol. 8, 2002, pages 827 - 837
KANDEL RA; GRYNPAS M; PILLIAR R; LEE J; WANG J; WALDMAN S ET AL., BIOMATERIALS, vol. 27, 2006, pages 4120 - 4131
KON E; GOBBI A; FILARDO G; DELCOGLIANO M; ZAFFAGNINI S; MARCACCI M., AM J SPORTS MED, vol. 37, 2009, pages 33 - 41
BASAD E; ISHAQUE B; BACHMANN G; STURZ H; STEINMEYER J., KNEE SURG SPORTS TRAUMATOL ARTHROSC, vol. 18, 2010, pages 519 - 527
SHEN C, MA J; CHEN XD; DAI LY., KNEE SURG SPORTS TRAUMATOL ARTHROSC, vol. 17, 2009, pages 1406 - 1411
GOMOLLAH; MADRYH; KNUTSENG; VANDIJKN; SEILR; BRITTBERG M ET AL., KNEE SURG SPORTS TRAUMATOL ARTHROSC, vol. 18, 2010, pages 434 - 447
KONE; DELCOGLIANO M; FILARDO G; BUSACCA M; DI MARTINO A; MARCACCI M., AM J SPORTS MED, vol. 39, 2011, pages 1180 - 1190
MINAS T; GOMOLL AH; ROSENBERGER R; ROYCE RO; BRYANT T., AM J SPORTS MED, vol. 37, 2009, pages 902 - 908
WAKITANI S; GOTO T; PINEDA SJ; YOUNG RG; MANSOUR JM; CAPLAN AI ET AL., JBONE JOINT SURG AM, vol. 76, 1994, pages 579 - 592
CHEN H; CHEVRIER A; HOEMANN CD; SUN J; OUYANG W; BUSCHMANN MD., AM J SPORTS MED, 2011
BEDI A; FEELEY BT; WILLIAMS RJ, 3RD., J BONE JOINT SURG AM, vol. 92, 2010, pages 994 - 1009
VASARA AI; HYTTINENMM; LAMMI MJ; LAMMI PE; LANGSJO TK; LINDAHL A ET AL., CALCIF TISSUE INT, vol. 74, 2004, pages 107 - 114
LIU G; KAWAGUCHI H; OGASAWARA T; ASAWA Y; KISHIMOTO J; TAKAHASHI T ET AL., J BIOL CHEM, vol. 282, 2007, pages 20407 - 20415
ANDOW; TATEISHI K; KATAKAI D; HART DA; HIGUCHI C; NAKATA K ET AL., TISSUE ENG PART A, vol. 14, 2008, pages 2041 - 2049
TISSUE ENGINEERING: PART A, vol. 6, 2010, pages 3413 - 3426
SANCHEZ ET AL., STEM CELLS, vol. 29, 2011, pages 251 - 262
Attorney, Agent or Firm:
YAMAMOTO, Shusaku et al. (JP)
Shusaku Yamamoto (JP)
Shusaku Yamamoto (JP)
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