Title:
SCAFFOLD, LOADED WITH ADIPOSE-DERIVED STEM CELLS OVEREXPRESSING PGC-1Α, FOR PREVENTING OR TREATING LIVER FIBROSIS
Document Type and Number:
WIPO Patent Application WO/2023/120971
Kind Code:
A1
Abstract:
The present invention relates to a scaffold for preventing or treating liver fibrosis and, more specifically, to a scaffold, loaded with adipose-derived stem cells overexpressing PGC-1α, for preventing or treating liver fibrosis, the adipose-derived stem cells being prepared by transforming adipose-derived stem cells with a vector comprising a gene that encodes PGC-1α. The scaffold according to the present invention induces a decrease in the blood concentration of alanine transaminases (ALT), a decrease in the expression of liver fibrosis markers, an increase in the expression of cell proliferation markers, and an increase in the expression of anti-apoptotic markers so as to exhibit excellent liver fibrosis treatment effects, and thus can be developed as an active ingredient of a composition for preventing, treating or alleviating liver fibrosis.
Inventors:
KIM SE JOON (KR)
KIM OK-HEE (KR)
KIM OK-HEE (KR)
Application Number:
PCT/KR2022/017468
Publication Date:
June 29, 2023
Filing Date:
November 08, 2022
Export Citation:
Assignee:
CATHOLIC UNIV KOREA IND ACADEMIC COOPERATION FOUNDATION (KR)
International Classes:
A61K35/28; A61K38/17; A61L27/38; A61L27/54; A61L27/56; A61P1/16; A61P43/00
Domestic Patent References:
| WO2013017699A1 | 2013-02-07 |
Foreign References:
| KR20160106795A | 2016-09-13 | |||
| KR20210084883A | 2021-07-08 |
Other References:
LEE JAEIM, KIM OK-HEE, LEE SANG CHUL, KIM KEE-HWAN, SHIN JIN SUN, HONG HA-EUN, CHOI HO JOONG, KIM SAY-JUNE: "Enhanced Therapeutic Potential of the Secretome Released from Adipose-Derived Stem Cells by PGC-1α-Driven Upregulation of Mitochondrial Proliferation", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, no. 22, 8 November 2019 (2019-11-08), pages 5589, XP093073686, DOI: 10.3390/ijms20225589
DAEYOUNG YOON, BYUNG-JAE KANG, YONGSUN KIM, SEUNG HOON LEE, DAEUN RHEW, WAN HEE KIM, OH-KYEONG KWEON: "Effect of serum-derived albumin scaffold and canine adipose tissue-derived mesenchymal stem cells on osteogenesis in canine segmental bone defect model", JOURNAL OF VETERINARY SCIENCE, KOREAN SOCIETY OF VETERINARY SCIENCE, SUWON, KR, vol. 16, no. 4, 1 January 2015 (2015-01-01), KR , pages 397 - 404, XP055756403, ISSN: 1229-845X, DOI: 10.4142/jvs.2015.16.4.397
DAEYOUNG YOON, BYUNG-JAE KANG, YONGSUN KIM, SEUNG HOON LEE, DAEUN RHEW, WAN HEE KIM, OH-KYEONG KWEON: "Effect of serum-derived albumin scaffold and canine adipose tissue-derived mesenchymal stem cells on osteogenesis in canine segmental bone defect model", JOURNAL OF VETERINARY SCIENCE, KOREAN SOCIETY OF VETERINARY SCIENCE, SUWON, KR, vol. 16, no. 4, 1 January 2015 (2015-01-01), KR , pages 397 - 404, XP055756403, ISSN: 1229-845X, DOI: 10.4142/jvs.2015.16.4.397
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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