Title:
SCAFFOLD PREPARING METHOD AND SCAFFOLD PREPARED THEREBY
Document Type and Number:
WIPO Patent Application WO/2016/195181
Kind Code:
A1
Abstract:
The present invention relates to a scaffold preparing method and a scaffold prepared thereby and, more specifically, to a scaffold preparing method for promoting bone regeneration by physically and chemically containing collagen and SDF-1 in a scaffold, and to a scaffold prepared thereby. The present invention is characterized by a scaffold and a preparing method therefor, wherein a surface of the scaffold is treated with 3-APTES to allow collagen and SDF-1 to physically and chemically adhere to the scaffold, so that an integrin is determined as a suitable extracellular matrix and the release rate of SDF-1 is not rapidly changed even with the passage of time, and thus the period of time for recovering the site of bone loss is shortened.
Inventors:
LEE DUK HYUN (KR)
MIN WOO KIE (KR)
KIM HYEON JUN (KR)
YANG JAE HYUK (KR)
YANG JAE HYUK (KR)
WANG LIH (KR)
LEE DONG HOON (KR)
MIN WOO KIE (KR)
KIM HYEON JUN (KR)
YANG JAE HYUK (KR)
YANG JAE HYUK (KR)
WANG LIH (KR)
LEE DONG HOON (KR)
Application Number:
PCT/KR2015/011559
Publication Date:
December 08, 2016
Filing Date:
October 30, 2015
Export Citation:
Assignee:
OSSGEN (KR)
LEE DUK HYUN (KR)
LEE DUK HYUN (KR)
International Classes:
A61L27/34; A61L27/24; A61L27/36; A61L27/42
Other References:
BALASUNDARAM, GANESAN ET AL.: "Using Hydroxyapatite Nanoparticles and Decreased Crystallinity to Promote Osteoblast Adhesion Similar to Functionalizing with RGD", BIOMATERIALS, vol. 27, no. 14, 2006, pages 2798 - 2805, XP027951039
ZHANG, WEI ET AL.: "The Use of Type 1 Collagen Scaffold Containing Stromal Cell -Derived Factor-1 to Create A Matrix Environment Conducive to Partial-Thickness Cartilage Defects Repair", BIOMATERIALS, vol. 34, no. 3, 2013, pages 713 - 723, XP055332381
KWAK, KYUNG - A. ET AL.: "In Vitro and In Vivo Studies of Three Dimensional Porous Composites of Biphasic Calcium Phosphate/Polycaprolactone: Effect of Bio-Functionalization for Bone Tissue Engineering", APPLIED SURFACE SCIENCE, vol. 301, 2014, pages 307 - 314, XP028837262
FERRARIS, SARA ET AL.: "Surface Functionalization of 3D Glass-Cetamic Porous Scaffolds for Enhanced Mineralization In Vitro", APPLIED SURFACE SCIENCE, vol. 271, 2013, pages 412 - 420, XP029003376
BLADERGROEN, BELLINDA A. ET AL.: "In Vivo Recruitment of Hematopoietic Cells Using Stromal Cell -derived Factor 1 Alpha-loaded Heparinized Three-Dimensional Collagen Scaffolds", TISSUE ENGINEERING: PART A, vol. 15, no. 7, 2009, pages 1591 - 1599
ZHANG, WEI ET AL.: "The Use of Type 1 Collagen Scaffold Containing Stromal Cell -Derived Factor-1 to Create A Matrix Environment Conducive to Partial-Thickness Cartilage Defects Repair", BIOMATERIALS, vol. 34, no. 3, 2013, pages 713 - 723, XP055332381
KWAK, KYUNG - A. ET AL.: "In Vitro and In Vivo Studies of Three Dimensional Porous Composites of Biphasic Calcium Phosphate/Polycaprolactone: Effect of Bio-Functionalization for Bone Tissue Engineering", APPLIED SURFACE SCIENCE, vol. 301, 2014, pages 307 - 314, XP028837262
FERRARIS, SARA ET AL.: "Surface Functionalization of 3D Glass-Cetamic Porous Scaffolds for Enhanced Mineralization In Vitro", APPLIED SURFACE SCIENCE, vol. 271, 2013, pages 412 - 420, XP029003376
BLADERGROEN, BELLINDA A. ET AL.: "In Vivo Recruitment of Hematopoietic Cells Using Stromal Cell -derived Factor 1 Alpha-loaded Heparinized Three-Dimensional Collagen Scaffolds", TISSUE ENGINEERING: PART A, vol. 15, no. 7, 2009, pages 1591 - 1599
Attorney, Agent or Firm:
AHN, Kyung Ju (KR)
안경주 (KR)
안경주 (KR)
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