Title:
SCAFFOLD
Document Type and Number:
WIPO Patent Application WO/2010/109226
Kind Code:
A3
Abstract:
The present invention provides a polymeric scaffold containing an antibacterial photoactive drug and optionally comprising seeded cells such as stem cells. The invention also includes methods of using the scaffold for tissue regeneration, prevention or reduction of infection whilst tissue regeneration occurs, methods for improving graft or implant survival, promoting scaffold integration and tissue repair and wound healing.
Inventors:
WOOD SIMON (GB)
YANG XUEBIN (GB)
DE MATAS MARCEL (GB)
IDDON PETER (GB)
RAXWORTHY MICHAEL (GB)
YANG XUEBIN (GB)
DE MATAS MARCEL (GB)
IDDON PETER (GB)
RAXWORTHY MICHAEL (GB)
Application Number:
PCT/GB2010/050485
Publication Date:
March 03, 2011
Filing Date:
March 23, 2010
Export Citation:
Assignee:
UNIV LEEDS (GB)
UNIV BRADFORD (GB)
NEOTHERIX LTD (GB)
WOOD SIMON (GB)
YANG XUEBIN (GB)
DE MATAS MARCEL (GB)
IDDON PETER (GB)
RAXWORTHY MICHAEL (GB)
UNIV BRADFORD (GB)
NEOTHERIX LTD (GB)
WOOD SIMON (GB)
YANG XUEBIN (GB)
DE MATAS MARCEL (GB)
IDDON PETER (GB)
RAXWORTHY MICHAEL (GB)
International Classes:
A61L27/18; A61L27/54; A61L27/56
Domestic Patent References:
| WO2007132186A2 | 2007-11-22 |
Other References:
KIM K ET AL: "Incorporation and controlled release of a hydrophilic antibiotic using poly(lactide-co-glycolide)-based electrospun nanofibrous scaffolds", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 98, no. 1, 23 July 2004 (2004-07-23), pages 47 - 56, XP004520545, ISSN: 0168-3659, DOI: DOI:10.1016/J.JCONREL.2004.04.009
DONNELLY ET AL: "Potential of photodynamic therapy in treatment of fungal infections of the mouth. Design and characterisation of a mucoadhesive patch containing toluidine blue O", JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B: BIOLOGY, ELSEVIER SCIENCE S.A., BASEL, CH, vol. 86, no. 1, 6 December 2006 (2006-12-06), pages 59 - 69, XP005794973, ISSN: 1011-1344, DOI: DOI:10.1016/J.JPHOTOBIOL.2006.07.011
DONNELLY ET AL: "Potential of photodynamic therapy in treatment of fungal infections of the mouth. Design and characterisation of a mucoadhesive patch containing toluidine blue O", JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B: BIOLOGY, ELSEVIER SCIENCE S.A., BASEL, CH, vol. 86, no. 1, 6 December 2006 (2006-12-06), pages 59 - 69, XP005794973, ISSN: 1011-1344, DOI: DOI:10.1016/J.JPHOTOBIOL.2006.07.011
Attorney, Agent or Firm:
HARRISON GODDARD FOOTE (Belgrave StreetLeeds, Yorkshire LS2 8DD, GB)
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