Title:
SCALABLE HIGH RECOVERY METHODS FOR PRODUCING HIGH YIELD RECOMBINANT ADENO-ASSOCIATED VIRAL (RAAV) VECTOR AND RECOMBINANT ADENO-ASSOCIATED VIRAL (RAAV) VECTORS PRODUCED THEREBY
Document Type and Number:
WIPO Patent Application WO/2018/017956
Kind Code:
A3
Abstract:
Provided are methods for producing recombinant adeno-associated virus (rAAV) vector particles at high recovery or high titer. Also provided are methods that concentrate rAAV vectors to a high concentration, for example, up to 5E+13 (5x1013) vector genomes per milliliter (Vg/ml) with little if any rAAV aggregates.
Inventors:
QU GUANG (US)
WRIGHT JOHN FRASER (US)
OH YOUNGHOON (US)
WANG YUHUAN (US)
ZHANG HAIBO (US)
DUNCAN LAURA (US)
WRIGHT JOHN FRASER (US)
OH YOUNGHOON (US)
WANG YUHUAN (US)
ZHANG HAIBO (US)
DUNCAN LAURA (US)
Application Number:
PCT/US2017/043291
Publication Date:
March 08, 2018
Filing Date:
July 21, 2017
Export Citation:
Assignee:
SPARK THERAPEUTICS INC (US)
International Classes:
C12N15/861; A61K48/00; C07K2/00; C12N7/00; C12N15/64
Foreign References:
| US20130072548A1 | 2013-03-21 | |||
| US20150275186A1 | 2015-10-01 | |||
| US20160024139A1 | 2016-01-28 | |||
| US20110165645A1 | 2011-07-07 |
Other References:
See also references of EP 3488007A4
Attorney, Agent or Firm:
BEDGOOD, Robert M. (US)
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