Title:
SCANNING PROBE MICROSCOPE
Document Type and Number:
WIPO Patent Application WO/2013/051094
Kind Code:
A1
Abstract:
In order to measure the arrangement structure of water molecules at a specimen-culture fluid interface in a culture fluid, the irregularity of the surface of a specimen in the culture fluid, potential distribution, and composition distributions, arrangement structures, and the like of molecules, protein, and the like with high spatial resolution, a scanning probe microscope is provided with a probe (1), a specimen holder (11) in which a specimen (3) is mounted, an oscillator (2) which displaces the position of the probe, pulse laser beams (22, 23) which are incident on a region measured by the probe in the specimen, a filter-equipped detector (25) which measures the intensity of output light (24) outputted from the specimen by energy spectroscopy, a scanning mechanism (31) which moves the specimen holder, and a control device (26), and measures the shape of the surface of the specimen, and linear/nonlinear optical characteristics. The probe enhanced detection efficiency is optimized by periodically displacing the position of the probe of the oscillator and maximizing the output light intensity dependent on the distance between the probe and the specimen by the control device.
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Inventors:
HASHIZUME TOMIHIRO (JP)
HEIKE SEIJI (JP)
YAMAMOTO TSUYOSHI (JP)
KOIZUMI HIDEAKI (JP)
HEIKE SEIJI (JP)
YAMAMOTO TSUYOSHI (JP)
KOIZUMI HIDEAKI (JP)
Application Number:
PCT/JP2011/072812
Publication Date:
April 11, 2013
Filing Date:
October 03, 2011
Export Citation:
Assignee:
HITACHI LTD (JP)
HASHIZUME TOMIHIRO (JP)
HEIKE SEIJI (JP)
YAMAMOTO TSUYOSHI (JP)
KOIZUMI HIDEAKI (JP)
HASHIZUME TOMIHIRO (JP)
HEIKE SEIJI (JP)
YAMAMOTO TSUYOSHI (JP)
KOIZUMI HIDEAKI (JP)
International Classes:
G01Q30/02; G01N21/27; G01Q60/18
Foreign References:
| JP2010071871A | 2010-04-02 | |||
| JP2007132781A | 2007-05-31 | |||
| JP2010066140A | 2010-03-25 |
Other References:
AKIHIDE WADA ET AL.: "Surface Vibrational Spectroscopy by Sum Frequency Generation", JOURNAL OF THE SPECTROSCOPICAL RESEARCH OF JAPAN, vol. 42, no. 3, 30 June 1993 (1993-06-30), pages 140 - 148
AKIRA YAMAGUCHI ET AL.: "Analysis of Associated Structures of Rhodamine B Adsorbed at Interfaces by Second Harmonic Generation Spectroscopy", JOURNAL OF JAPAN SOCIETY FOR ANALYTICAL CHEMISTRY, vol. 55, no. 7, 29 September 2006 (2006-09-29), pages 457 - 465
MAMORU HASHIMOTO ET AL.: "Coherent Anti-Stokes Raman Scattering Microscopy", IEICE TECHNICAL REPORT. MBE, ME AND BIO CYBERNETICS, vol. 102, no. 387, 11 October 2002 (2002-10-11), pages 25 - 28
AKIRA YAMAGUCHI ET AL.: "Analysis of Associated Structures of Rhodamine B Adsorbed at Interfaces by Second Harmonic Generation Spectroscopy", JOURNAL OF JAPAN SOCIETY FOR ANALYTICAL CHEMISTRY, vol. 55, no. 7, 29 September 2006 (2006-09-29), pages 457 - 465
MAMORU HASHIMOTO ET AL.: "Coherent Anti-Stokes Raman Scattering Microscopy", IEICE TECHNICAL REPORT. MBE, ME AND BIO CYBERNETICS, vol. 102, no. 387, 11 October 2002 (2002-10-11), pages 25 - 28
Attorney, Agent or Firm:
POLAIRE I. P. C. (JP)
Polaire Intellectual Property Corporation (JP)
Polaire Intellectual Property Corporation (JP)
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Claims: