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Title:
SCAP GENE MUTANT AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/107545
Kind Code:
A1
Abstract:
Provided are a nucleic acid of an isolated encoding SCAP mutant, an isolated SCAP polypeptide, a method and a system for screening for biological samples that easily contract premature myocardial infarction, and a kit used to screen for biological samples that easily contract premature myocardial infarction. The nucleic acid of the isolated encoding SCAP mutant has c.3035C>T mutation as compared with SEQ ID NO:1.

Inventors:
CHEN HONG (CN)
GAO YUANFENG (CN)
SONG JUNXIAN (CN)
LI ZHONGYOU (CN)
LI SUFANG (CN)
Application Number:
PCT/CN2016/097352
Publication Date:
June 29, 2017
Filing Date:
August 30, 2016
Export Citation:
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Assignee:
PEKING UNIV PEOPLE'S HOSPITAL (CN)
International Classes:
C12N15/12; C07K14/46; C12M1/34; C12N1/21; C12N5/10; C12N15/70; C12N15/85; C12Q1/68
Foreign References:
CN105441454A2016-03-30
Other References:
LIU, X. ET AL.: "Interactions among genetic variants from SREBP2 activating-related pathway on risk of coronary heart disease in Chinese Han population", ATHEROSCLEROSIS, vol. 208, no. 2, 31 December 2010 (2010-12-31), pages 421 - 426, XP026875093, ISSN: 1879-1484
WANG, WEI ET AL.: "The Ile796Val Polymorphism of the Human SCAP Gene in Patients with Isehemic Cerebral and Heart Diseases", CHINESE JOURNAL OF GERONTOLOGY, vol. 24, no. 3, 31 March 2003 (2003-03-31), pages 201 - 203, ISSN: 1005-9202
FRIEDLANDER, Y. ET AL.: "SREBP-2 and SCAP isoforms and risk of early onset myocardial infarction", ATHEROSCLEROSIS, vol. 196, no. 2, 31 December 2008 (2008-12-31), pages 896 - 904, XP022438220, ISSN: 1879-1484
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (CN)
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