SCAR DIAGNOSTIC REAGENT AND USE THEREOF - SHANGHAI 9TH PEOPLES HOSPITAL SHANGHAI JIAOTONG UNIV SCHOOL MEDICINE

Title:

SCAR DIAGNOSTIC REAGENT AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/284660

Kind Code:

A1

Abstract:

A scar diagnosis reagent and the use thereof, which use comprises the use of a detection reagent of a CD3 +CD8 + cytotoxic T cell, NKG2A, KLRC1, or soluble human leukocyte antigen-E (sHLA-E) in the preparation of a reagent or kit for keloid detection and/or prognosis. sHLA-E as a diagnostic marker can be used for the differential diagnosis of a hypertrophic scar and keloids, which are traditionally considered to be pathological scars, and is used to judge the effect of keloid treatments.

More Like This:

WO/2014/111443	PREDICTION OF KIDNEY DISEASE PROGRESSION USING HOMOARGININE AS A BIOMARKER
WO/2022/183010	ELECTRON TRANSFER DISSOCIATION AND MASS SPECTROMETRY FOR IMPROVED PROTEIN SEQUENCING OF MONOCLONAL ANTIBODIES
WO/2012/105590	DETERMINATION MARKER FOR NON-ALCOHOLIC STEATOHEPATITIS, AND METHOD FOR DIAGNOSING NON-ALCOHOLIC STEATOHEPATITIS USING THE MARKER AS MEASURE

Inventors:

ZHANG YIXIN (CN)
XU HENG (CN)

Application Number:

PCT/CN2022/104807

Publication Date:

January 19, 2023

Filing Date:

July 11, 2022

Export Citation:

Click for automatic bibliography generation Help

Assignee:

SHANGHAI 9TH PEOPLES HOSPITAL SHANGHAI JIAOTONG UNIV SCHOOL MEDICINE (CN)

International Classes:

G01N33/68; A61K31/7088; A61K39/395; A61K45/00; A61P17/02

Foreign References:

US20190011457A1	2019-01-10
CN112485434A	2021-03-12
CN112839664A	2021-05-25

Other References:

XU, HENG ET AL.: "Downregulated cytotoxic CD8+ T-cell identfies with the NKG2A-soluble HLA-E axis as a predictive biomarker and potential therapeutic target in keloids", CELLULAR & MOLECULAR IMMUNOLOGY, vol. 19, 17 January 2022 (2022-01-17), XP037788973, ISSN: 2042-0226, DOI: 10.1038/s41423-021-00834-1
BAGABIR, R. ET AL.: "Site-speciﬁc immunophenotyping of keloid disease demonstrates immune upregulation and the presence of lymphoid aggregates", BRITISH JOURNAL OF DERMATOLOGY, vol. 167, no. 5, 29 October 2012 (2012-10-29), XP009513196, ISSN: 1365-2133, DOI: 10.1111/j.1365-2133.2012.11190.x

Attorney, Agent or Firm:

SHANGHAI SHENHUI PATENT AGENT CO., LTD. (CN)

Download PDF:

View/Download PDF PDF Help

Previous Patent: CHANNEL INFORMATION OBTAINING METHOD AND COMMUNICATION APPARATUS

Next Patent: ON-BOARD DISINFECTION SYSTEM AND METHOD FOR TRUNK, AND CORRESPONDING VEHICLE AND PROGRAM PRODUCT