Title:
SCAR REDUCTION
Document Type and Number:
WIPO Patent Application WO2000051566
Kind Code:
A9
Abstract:
A method of reducing scar formation at a wound site includes contacting the wound site with an effective scar reducing amount of a cross-linked polysaccharide having a positive charge and thereby reducing scar formation as the wound site heals. Such polysaccharide includes bioabsorbable cross-linked dextrans or alginates. The positive charge may be provided by diethylaminoethyl (DEAE) moieties. The cross-linked polysaccharide can be applied to the wound site as a powder or bead. The cross-linked polysaccharide may also be contained in a composition including a pharmaceutically acceptable vehicle. Biocompatible surgical devices are provided with an effective scar reducing amount of a cross-linked polysaccharide having a positive charge which reduce scar formation at healing wound sites. A method of reducing TGF- beta activity is also provided.
Inventors:
GRUSKIN ELLIOTT A
CHRISTOFOROU CHRISTOPHER T
CHRISTOFOROU CHRISTOPHER T
Application Number:
PCT/US2000/005610
Publication Date:
November 08, 2001
Filing Date:
March 03, 2000
Export Citation:
Assignee:
UNITED STATES SURGICAL CORP (US)
International Classes:
A61K31/715; A61K31/738; A61L17/14; A61L27/34; (IPC1-7): A61K9/14; A61K31/715; A61L17/10; A61L27/20
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