Title:
SCHIZOPHRENIA ANIMAL MODEL AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2019/045273
Kind Code:
A1
Abstract:
The present invention relates to: a schizophrenia animal model which is a mouse in which an anoctamin 1 (ANO1) gene is specifically knocked out in cholinergic neurons of the medial habenula; and a preparation method therefor and the like. The schizophrenia animal model according to the present invention targets the medial habenula which is brain tissue playing a major role in the pathogenesis of schizophrenia, and it has been confirmed that when an ANO1 gene is specifically knocked out in the cholinergic neurons of the medial habenula, positive, negative and cognitive symptoms of schizophrenia are observed, thereby confirming that schizophrenia has been induced. Therefore, the animal model of the present invention is expected to be effectively useful in schizophrenia pathogenesis research and therapeutic agent development and screening.
Inventors:
PARK JAE-YONG (KR)
HWANG EUN MI (KR)
IM HEH-IN (KR)
CHO CHANG-HOON (KR)
LEE SANGJOON (KR)
HWANG EUN MI (KR)
IM HEH-IN (KR)
CHO CHANG-HOON (KR)
LEE SANGJOON (KR)
Application Number:
PCT/KR2018/008217
Publication Date:
March 07, 2019
Filing Date:
July 20, 2018
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
A01K67/027; G01N33/50
Foreign References:
| KR20170022715A | 2017-03-02 | |||
| KR101127756B1 | 2012-03-23 | |||
| KR20150001435A | 2015-01-06 |
Other References:
SATOU: "Temporal Expression Patterns of Clock Genes and Aquaporin 5/Anoctamin 1 in Rat Submandibular Gland Cells", FRONTIERS IN PHYSIOLOGY, vol. 8, 23 May 2017 (2017-05-23), pages 1 - 8, XP055582057
AMJAD: "Conditional knockout of TMEM16A/anoctaminl abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons", THE JOURNAL OF GENERAL PHYSIOLOGY, vol. 145, no. 4, 16 March 2015 (2015-03-16), pages 285 - 301, XP055582058
AMJAD: "Conditional knockout of TMEM16A/anoctaminl abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons", THE JOURNAL OF GENERAL PHYSIOLOGY, vol. 145, no. 4, 16 March 2015 (2015-03-16), pages 285 - 301, XP055582058
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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