Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
SCHWANN CELL PRECURSOR AND METHOD FOR PREPARING SCHWANN CELL DIFFERENTIATED THEREFROM
Document Type and Number:
WIPO Patent Application WO/2018/135907
Kind Code:
A1
Abstract:
The present invention provides a method for preparing a Schwann cell precursor from a pluripotent stem cell, a method for preparing a Schwann cell precursor from an adult cell, and a method for preparing a Schwann cell from the prepared Schwann cell precursor. Also, the present invention provides a pharmaceutical composition comprising the Schwann cell precursor and the Schwann cell for preventing or treating a nerve disease, a cell therapy product and a preparation method therefor, a composition for inducing direct differentiation from a pluripotent stem cell to a Schwann cell, and a composition for differentiation from a Schwann cell precursor to a Schwann cell. Provided also are a Schwann cell precursor or a Schwann cell prepared by the method, and a screening kit comprising the same. The method for preparing a Schwann cell precursor from a pluripotent stem cell or an adult cell according to the present invention can produce a Schwann cell precursor rapidly and effectively, and the Schwann cell prepared from a Schwann cell precursor has myelination potential and neurotrophic factor release activity, thus finding applications in the prevention or treatment of a nerve disease.

Inventors:
CHO, Yee Sook (125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, KR)
KIM, Han-Seop (125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, KR)
Application Number:
KR2018/000910
Publication Date:
July 26, 2018
Filing Date:
January 19, 2018
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, KR)
International Classes:
C12N5/079; A61K35/30; C12N5/071; G01N33/50
Domestic Patent References:
WO2016187135A12016-11-24
WO2016148656A12016-09-22
Foreign References:
KR20160086170A2016-07-19
KR20150015294A2015-02-10
Other References:
PETERSEN, GAYLE F. ET AL.: "Generation of Diverse Neural Cell Types through Direct Conversion", WORLD JOURNAL OF STEM CELLS, vol. 8, no. 2, 2016, pages 32 - 46, XP055505349
KIM, HAN-SEOP ET AL.: "Schwann Cell Precursors from Human Pluripotent Stem Cells as a Potential Therapeutic Target for Myelin Repair", STEM CELL REPORTS, vol. 8, no. 6, 6 June 2017 (2017-06-06), pages 1714 - 1726, XP055505353
Attorney, Agent or Firm:
SON, Min (Hanol Intellectual Property&Law, 6th Floor Daemyung,Tower, 135, Beobwon-ro,,Songpa-gu, Seoul, 05836, KR)
Download PDF: