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Title:
SCREENING MEHTOD FOR LIVER X RECEPTOR AGONISTS AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2009/143705
Kind Code:
A1
Abstract:
A screening method for liver X receptor agonists. By the method, cimicifugae extracts are screened as LXR agonists.

Inventors:
LIU SHENG-YUN (CN)
WEN WU-CHE (CN)
KUO MAO-TIEN (CN)
Application Number:
PCT/CN2009/000587
Publication Date:
December 03, 2009
Filing Date:
May 26, 2009
Export Citation:
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Assignee:
GOLDEN BIOTECHNOLOGY CORP (CN)
LIU SHENG-YUN (CN)
WEN WU-CHE (CN)
KUO MAO-TIEN (CN)
International Classes:
C12Q1/68; A61K36/29; B01D11/00; C12N15/09; G01N33/50
Domestic Patent References:
WO2002090375A22002-11-14
Foreign References:
CN1980919A2007-06-13
Other References:
"Symposia of the Sixth Academic Annual Meeting of Chinese Pharmaceutical Association", 2006, article ZHENQ ZHIHUI ET AL.: "Establishment of a high-throughput drug screening model for new PPAR a agonists based on mammalian one-hybrid system and study of"
See also references of EP 2339030A4
WILLY, P. J., UMESONO, K., ONG, E. S., EVANS, R. M., HEYMAN, R. A., MANGELSDORF, D. J.: "LXR, a nuclear receptor that defines a distinct retinoid response pathway", GENES DEV., vol. 9, no. 9, 1995, pages 1033 - 45
STEFFENSEN, K.R., GUSTAFSSON, J.A.: "Putative metabolic effects of the liver X receptor (LXR)", DIABETES, vol. 53, no. 1, 2004, pages 36 - 42
PROCTOR, G., JIANG, T., IWAHASHI, M., WANG, Z., LI, J., LEVI, M.: "Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes", DIABETES, vol. 55, no. 9, 2006, pages 2502 - 9
KOLDAMOVA, R. P., LEFTEROV, I. M., STAUFENBIEL, M., WOLFE, D., HUANG, S., GLORIOSO, J. C., WALTER, M., ROTH, M. G., LAZO, J. S.: "The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease", J BIOL CHEM. 11, vol. 280, no. 6, 2005, pages 4079 - 88
FUKUCHI, J., KOKONTIS, J. M., HIIPAKKA, R.A., CHUU, C.P., LIAO, S.: "Antiproliferative effect of liver X receptor agonists on LNCaP human prostate cancer cells", CANCER RES., vol. 64, no. 21, 1 November 2004 (2004-11-01), pages 7686 - 9
Attorney, Agent or Firm:
CHINA LONGRIVER PATENT & TRADEMARK OFFICE (Room 1502 A3 Nuoan Plaza,No.14A, Guanghuaq Road,Chaoyang District, Beijing 0, CN)
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