Title:
SCREENING METHOD FOR CONTINUOUS CULTURE CONDITIONS AND SCREENING DEVICE FOR CONTINUOUS CULTURE CONDITIONS
Document Type and Number:
WIPO Patent Application WO/2018/235441
Kind Code:
A1
Abstract:
Provided is a method and a device for screening continuous culture conditions, capable of selecting a cell line for continuous culture that hardly proliferates after reaching a steady state and that exhibits a high product generation rate with respect to the cell proliferation rate, and capable of selecting a continuous culture condition suitable for such cell line. This screening method and device are for selecting a suspension-type cell line for continuous culture on the basis of at least one index selected from: an index for the maximum {(product generation rate)/(cell proliferation rate)}; an index for the longest total time-period of a G0 period and a G1 period of the cell cycle; and an index for the minimum pathways in the metabolic flux.
Inventors:
SHIBUYA KEISUKE (JP)
MURAKAMI SEI (JP)
KONDOU TAKEYUKI (JP)
ISHIKAWA SHUTARO (JP)
MURAKAMI SEI (JP)
KONDOU TAKEYUKI (JP)
ISHIKAWA SHUTARO (JP)
Application Number:
PCT/JP2018/017808
Publication Date:
December 27, 2018
Filing Date:
May 08, 2018
Export Citation:
Assignee:
HITACHI LTD (JP)
ABLE CORP (JP)
ABLE CORP (JP)
International Classes:
C12N1/00; C12M1/00; C12M3/00
Foreign References:
| JP2008527991A | 2008-07-31 | |||
| JP2002527057A | 2002-08-27 | |||
| JPH07147991A | 1995-06-13 | |||
| JP2007020430A | 2007-02-01 |
Attorney, Agent or Firm:
ISONO INTERNATIONAL PATENT OFFICE, P.C. (JP)
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