Title:
SCREENING METHOD FOR EVALUATION OF BILAYER-DRUG INTERACTION IN LIPOSOMAL COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO2005034915
Kind Code:
A3
Abstract:
A method for generating a correlation between at least one thermal property of a liposomal carrier in the presence of a therapeutic agent and a pharmacokinetic property for the therapeutic agent in the liposomal carrier and using the correlation for predicting the pharmacokinetic property of the liposomal carrier in the presence of any therapeutic agent in a liposomal carrier.
Inventors:
ZHANG YUANPENG (US)
Application Number:
PCT/US2004/032095
Publication Date:
November 03, 2005
Filing Date:
October 01, 2004
Export Citation:
Assignee:
ALZA CORP (US)
ZHANG YUANPENG (US)
ZHANG YUANPENG (US)
International Classes:
A61K9/127; (IPC1-7): A61K9/127
Foreign References:
| US4427649A | 1984-01-24 | |||
| EP0331504A1 | 1989-09-06 |
Other References:
ZHANG YUANPENG ET AL: "Studies of lipid membrane - drug interactions using DSC and its correlation with the pharmacokinetics of liposome encapsulated drugs.", BIOPHYSICAL JOURNAL, vol. 86, no. 1, January 2004 (2004-01-01), & 48TH ANNUAL MEETING OF THE BIOPHYSICAL SOCIETY; BALTIMORE, MD, USA; FEBRUARY 14-18, 2004, pages 36a, XP008051851, ISSN: 0006-3495
YU-LI LO ET AL: "PROTEIN LOCATION IN LIPOSOMES, A DRUG CARRIER: A PREDICTION BY DIFFERENTIAL SCANNING CALORIMETRY", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON, US, vol. 84, no. 7, 1 July 1995 (1995-07-01), pages 805 - 814, XP000512236, ISSN: 0022-3549
ANDERSON KEITH E. ET AL: "Formulation and evaluation of a folic acid receptor targeted orla vancomycin liposomal dosage form", PHARMACEUTICAL RESEARCH, vol. 18, no. 3, 2001, pages 316 - 322, XP008051854
ZHANG YUAN-PENG ET AL: "Interaction of a Peptide Model of a Hydrophobic Transmembrane alpha-Helical Segment of a membrane Protein with Phosphatidylethanolamine Bilayers: Differential Scanning Calorimetric and Fourier Transform Infrared Spectroscopic Studies", BIOPHYSICAL JOURNAL, vol. 68, no. 3, 1995, pages 847 - 857, XP008051850, ISSN: 0006-3495
AMSELEM S ET AL: "In vitro tests to predict in vivo performance of liposomal dosage forms.", CHEMISTRY AND PHYSICS OF LIPIDS. SEP 1993, vol. 64, no. 1-3, September 1993 (1993-09-01), pages 219 - 237, XP008051853, ISSN: 0009-3084
SHABBITS J A ET AL: "Development of an in vitro drug release assay that accurately predicts in vivo drug retention for liposome-based delivery systems", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 84, no. 3, 5 December 2002 (2002-12-05), pages 161 - 170, XP004395987, ISSN: 0168-3659
TSUCHIHASHI M ET AL: "Development of a pharmacokinetic/pharmacodynamic (PK/PD)-simulation system for doxorubicin in long circulating liposomes in mice using peritoneal P388", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 61, no. 1-2, 27 August 1999 (1999-08-27), pages 9 - 19, XP004362960, ISSN: 0168-3659
YU-LI LO ET AL: "PROTEIN LOCATION IN LIPOSOMES, A DRUG CARRIER: A PREDICTION BY DIFFERENTIAL SCANNING CALORIMETRY", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON, US, vol. 84, no. 7, 1 July 1995 (1995-07-01), pages 805 - 814, XP000512236, ISSN: 0022-3549
ANDERSON KEITH E. ET AL: "Formulation and evaluation of a folic acid receptor targeted orla vancomycin liposomal dosage form", PHARMACEUTICAL RESEARCH, vol. 18, no. 3, 2001, pages 316 - 322, XP008051854
ZHANG YUAN-PENG ET AL: "Interaction of a Peptide Model of a Hydrophobic Transmembrane alpha-Helical Segment of a membrane Protein with Phosphatidylethanolamine Bilayers: Differential Scanning Calorimetric and Fourier Transform Infrared Spectroscopic Studies", BIOPHYSICAL JOURNAL, vol. 68, no. 3, 1995, pages 847 - 857, XP008051850, ISSN: 0006-3495
AMSELEM S ET AL: "In vitro tests to predict in vivo performance of liposomal dosage forms.", CHEMISTRY AND PHYSICS OF LIPIDS. SEP 1993, vol. 64, no. 1-3, September 1993 (1993-09-01), pages 219 - 237, XP008051853, ISSN: 0009-3084
SHABBITS J A ET AL: "Development of an in vitro drug release assay that accurately predicts in vivo drug retention for liposome-based delivery systems", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 84, no. 3, 5 December 2002 (2002-12-05), pages 161 - 170, XP004395987, ISSN: 0168-3659
TSUCHIHASHI M ET AL: "Development of a pharmacokinetic/pharmacodynamic (PK/PD)-simulation system for doxorubicin in long circulating liposomes in mice using peritoneal P388", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 61, no. 1-2, 27 August 1999 (1999-08-27), pages 9 - 19, XP004362960, ISSN: 0168-3659
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