Title:
SCREENING STRATEGY FOR ANTICANCER DRUGS
Document Type and Number:
WIPO Patent Application WO2004014319
Kind Code:
A3
Abstract:
The invention provides methods and reagents for identifying compounds that growth inhibit or kill tumor cells.
More Like This:
Inventors:
BROUDE EUGENIA (US)
RONINSON IGOR B (US)
SWIFT MARI E (US)
RONINSON IGOR B (US)
SWIFT MARI E (US)
Application Number:
PCT/US2003/025221
Publication Date:
January 26, 2006
Filing Date:
August 13, 2003
Export Citation:
Assignee:
UNIV ILLINOIS (US)
BROUDE EUGENIA (US)
RONINSON IGOR B (US)
SWIFT MARI E (US)
BROUDE EUGENIA (US)
RONINSON IGOR B (US)
SWIFT MARI E (US)
International Classes:
A61K6/00; A61K45/00; A61P35/00; C12Q1/02; G01N33/50; G01N33/574; A61K; (IPC1-7): G01N33/53; A61K38/00; C07K5/00
Other References:
LANZINI ET AL.: "Transient S/G2 delay in adriamycin-treated C-3 human prostate cancer cells is followed by overaccumulation of cyclin B1 protein and induction of mitotic catastrophe.", FREE RADICAL BIOL MED, vol. 33, no. 2, 2002, pages S404
KUDRYAVETS ET AL.: "Dynamics of apoptotic events induced in human leukemia U-937 cells by tumor necrosis factor.", EXPERIMENTAL ONCOLOGY, vol. 18, December 1996 (1996-12-01), pages 353 - 365
COGSWELL ET AL.: "Dominant-negative Polo-like kinase-1 induces mitotic catastrophe independent of cdc25c function.", CELL GROWTH AND DIFFERENTIATION., vol. 11, December 2000 (2000-12-01), pages 615 - 623, XP002993292
ANDREASSEN ET AL.: "Neither p21-waf1 nor 14-3-3 o prevents G2 progression to mitotic catastrophe in human colon carcinoma cells after DNA damage, but p21 waf1 induces stable G1 arrest in resulting tetraploid cells.", CANCER RES., vol. 61, 15 October 2001 (2001-10-15), pages 7660 - 7668, XP002993293
CHANG ET AL.: "A senescene-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest exposure to anticancer agents.", CANCER RES., vol. 59, 1 August 1999 (1999-08-01), pages 3761 - 3767, XP002245658
See also references of EP 1578369A4
KUDRYAVETS ET AL.: "Dynamics of apoptotic events induced in human leukemia U-937 cells by tumor necrosis factor.", EXPERIMENTAL ONCOLOGY, vol. 18, December 1996 (1996-12-01), pages 353 - 365
COGSWELL ET AL.: "Dominant-negative Polo-like kinase-1 induces mitotic catastrophe independent of cdc25c function.", CELL GROWTH AND DIFFERENTIATION., vol. 11, December 2000 (2000-12-01), pages 615 - 623, XP002993292
ANDREASSEN ET AL.: "Neither p21-waf1 nor 14-3-3 o prevents G2 progression to mitotic catastrophe in human colon carcinoma cells after DNA damage, but p21 waf1 induces stable G1 arrest in resulting tetraploid cells.", CANCER RES., vol. 61, 15 October 2001 (2001-10-15), pages 7660 - 7668, XP002993293
CHANG ET AL.: "A senescene-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest exposure to anticancer agents.", CANCER RES., vol. 59, 1 August 1999 (1999-08-01), pages 3761 - 3767, XP002245658
See also references of EP 1578369A4
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