Title:
SCYLLA PARAMAMOSAIN ANTIBACTERIAL PEPTIDE SCYREPROCIN AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/103511
Kind Code:
A1
Abstract:
Provided are Scylla paramamosain antibacterial peptide Scyreprocin and an application thereof, wherein the amino acid sequence thereof comprises a sequence as shown in SEQ ID NO 01, and the antibacterial peptide is expressed and purified by using genetic engineering technology. The antibacterial peptide has advantages of wide antibacterial spectrum, good antibacterial effect, and fast sterilization rate, shows great application significance, and has good application in preparation of antibacterial agents. The antibacterial peptide has no cytotoxicity to mouse hepatocytes AML 12, human normal liver cells L02 and the like, and can be safely used for medical treatment or can be used as a feed composition.
Inventors:
WANG KEJIAN (CN)
YANG YING (CN)
CHEN FANGYI (CN)
CHEN YANCHAO (CN)
CHEN HUIYUN (CN)
PENG HUI (CN)
YANG YING (CN)
CHEN FANGYI (CN)
CHEN YANCHAO (CN)
CHEN HUIYUN (CN)
PENG HUI (CN)
Application Number:
PCT/CN2019/103237
Publication Date:
May 28, 2020
Filing Date:
August 29, 2019
Export Citation:
Assignee:
UNIV XIAMEN (CN)
International Classes:
C12N15/12; A61K38/17; A61P31/00; C07K14/435
Foreign References:
| CN105274134A | 2016-01-27 | |||
| CN103789317A | 2014-05-14 | |||
| CN102167736A | 2011-08-31 | |||
| CN104151414A | 2014-11-19 |
Other References:
XU, WANFANG ET AL.: "Recombinant Expression of the Anti-microbial Peptide, Scygonadin from Scylla Paramamosain in Pichia Pastoris and its Antimicrobial Activity", JOURNAL OF QUANZHOU NORMAL UNIVERSITY, vol. 29, no. 6, 30 November 2011 (2011-11-30)
PENG, YINHUI ET AL.: "Optimization of Prokaryotic Expression of Antibacterial Peptide hyastatin Gene in Scylla Paramamosain", BIOTECHNOLOGY BULLETIN, vol. 31, no. 7, 31 December 2015 (2015-12-31)
SHAN, Z. G. ET AL.: "The New Antimicrobial Pepetide SpHyastatin from the Mud Crab Scylla paramamosain with Multiple Antimicrobial Mechanisms and High Effect on Bacterial Infection", FRONTIERS IN MICROBIOLOGY, vol. 7, 21 July 2016 (2016-07-21), pages 1140, XP055709631
IMJONGJIRAK, C. ET AL.: "Two novel antimicrobial peptides, arasin-likeSp and GRPSp, from the mud crab Scylla paramamosain, exhibit the activity against some crustacean pathogenic bacteria", FISH & SHELLFISH IMMUNOLOGY, vol. 30, no. 2, 30 December 2010 (2010-12-30), pages 706 - 712, XP028358100
PENG, YINHUI ET AL.: "Optimization of Prokaryotic Expression of Antibacterial Peptide hyastatin Gene in Scylla Paramamosain", BIOTECHNOLOGY BULLETIN, vol. 31, no. 7, 31 December 2015 (2015-12-31)
SHAN, Z. G. ET AL.: "The New Antimicrobial Pepetide SpHyastatin from the Mud Crab Scylla paramamosain with Multiple Antimicrobial Mechanisms and High Effect on Bacterial Infection", FRONTIERS IN MICROBIOLOGY, vol. 7, 21 July 2016 (2016-07-21), pages 1140, XP055709631
IMJONGJIRAK, C. ET AL.: "Two novel antimicrobial peptides, arasin-likeSp and GRPSp, from the mud crab Scylla paramamosain, exhibit the activity against some crustacean pathogenic bacteria", FISH & SHELLFISH IMMUNOLOGY, vol. 30, no. 2, 30 December 2010 (2010-12-30), pages 706 - 712, XP028358100
Attorney, Agent or Firm:
SHOUCHUANG JUNHE PATENT AGENT CO., LTD.XIAMEN (CN)
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