Title:
SECRETED POLYPEPTIDE SPECIES REDUCED IN CARDIOVASCULAR DISORDERS
Document Type and Number:
WIPO Patent Application WO2005014635
Kind Code:
A3
Abstract:
The invention discloses human secreted potypeptides that circulate at a decreased level in the plasma of patients with cardiovascular disorders. The invention also provides methods of using compositions including the polypeptides, polynucleotides encoding them, and antibodies specific for these polypeptides, for diagnosis, prognosis, and for drug development.
Inventors:
ARGOUD-PUY GUILAINE (CH)
BEDERR NASSIMA (CH)
BOUGUELERET LYDIE (CH)
CUSIN ISABELLE (CH)
MAHE EVE (CH)
NIKNEJAD ANNE (CH)
REFFAS SAMIA (CH)
ROSE KEITH (CH)
SAUDRAIS CEDRIC (CH)
BEDERR NASSIMA (CH)
BOUGUELERET LYDIE (CH)
CUSIN ISABELLE (CH)
MAHE EVE (CH)
NIKNEJAD ANNE (CH)
REFFAS SAMIA (CH)
ROSE KEITH (CH)
SAUDRAIS CEDRIC (CH)
Application Number:
PCT/EP2004/007842
Publication Date:
May 19, 2005
Filing Date:
July 15, 2004
Export Citation:
Assignee:
GENOVA LTD
NOVARTIS PHARMA GMBH (AT)
ARGOUD-PUY GUILAINE (CH)
BEDERR NASSIMA (CH)
BOUGUELERET LYDIE (CH)
CUSIN ISABELLE (CH)
MAHE EVE (CH)
NIKNEJAD ANNE (CH)
REFFAS SAMIA (CH)
ROSE KEITH (CH)
SAUDRAIS CEDRIC (CH)
NOVARTIS PHARMA GMBH (AT)
ARGOUD-PUY GUILAINE (CH)
BEDERR NASSIMA (CH)
BOUGUELERET LYDIE (CH)
CUSIN ISABELLE (CH)
MAHE EVE (CH)
NIKNEJAD ANNE (CH)
REFFAS SAMIA (CH)
ROSE KEITH (CH)
SAUDRAIS CEDRIC (CH)
International Classes:
C07K14/47; C12N15/56; G01N33/68; (IPC1-7): C07K14/47; A61K38/47; C12N15/56; C12Q1/34; G01N33/573
Domestic Patent References:
| WO2001012781A1 | 2001-02-22 |
Foreign References:
| US20030096756A1 | 2003-05-22 | |||
| US5837841A | 1998-11-17 |
Other References:
PATARD LOUIS ET AL: "An insight into the role of human pancreatic lithostathine.", JOP [ELECTRONIC RESOURCE] : JOURNAL OF THE PANCREAS. MAR 2003, vol. 4, no. 2, March 2003 (2003-03-01), pages 92 - 103, XP001203943, ISSN: 1590-8577
NOJI YOSHIHIRO ET AL: "Circulating matrix metalloproteinases and their inhibitors in premature coronary atherosclerosis", CLINICAL CHEMISTRY AND LABORATORY MEDICINE, vol. 39, no. 5, May 2001 (2001-05-01), pages 380 - 384, XP009040349, ISSN: 1434-6621
DUGI KLAUS A ET AL: "Low hepatic lipase activity is a novel risk factor for coronary artery disease", CIRCULATION, vol. 104, no. 25, 18 December 2001 (2001-12-18), pages 3057 - 3062, XP002307402, ISSN: 0009-7322
DZIELINSKA ZOFIA ET AL: "Decreased plasma concentration of a novel anti-inflammatory protein-adiponectin-in hypertensive men with coronary artery disease.", THROMBOSIS RESEARCH, vol. 110, no. 5-6, 15 June 2003 (2003-06-15), pages 365 - 369, XP002307403, ISSN: 0049-3848
NOJI YOSHIHIRO ET AL: "Circulating matrix metalloproteinases and their inhibitors in premature coronary atherosclerosis", CLINICAL CHEMISTRY AND LABORATORY MEDICINE, vol. 39, no. 5, May 2001 (2001-05-01), pages 380 - 384, XP009040349, ISSN: 1434-6621
DUGI KLAUS A ET AL: "Low hepatic lipase activity is a novel risk factor for coronary artery disease", CIRCULATION, vol. 104, no. 25, 18 December 2001 (2001-12-18), pages 3057 - 3062, XP002307402, ISSN: 0009-7322
DZIELINSKA ZOFIA ET AL: "Decreased plasma concentration of a novel anti-inflammatory protein-adiponectin-in hypertensive men with coronary artery disease.", THROMBOSIS RESEARCH, vol. 110, no. 5-6, 15 June 2003 (2003-06-15), pages 365 - 369, XP002307403, ISSN: 0049-3848
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