Title:
SECRETORY IMMUNOGLOBULIN A (SIGA)-BINDING NUCLEIC ACID MOLECULE, SENSOR FOR SIGA ANALYSIS, AND ANALYSIS METHOD FOR SIGA
Document Type and Number:
WIPO Patent Application WO/2018/051569
Kind Code:
A1
Abstract:
Provided is a novel molecule which can be used to detect sIgA. This secretory immunoglobulin A (sIgA)-binding nucleic acid is characterized by being a nucleic acid molecule having a dissociation constant for sIgA of 37.7 nM or less. For example, the nucleic acid preferably includes a polynucleotide having a base sequence of any of SEQ ID NO. 1-12, or a polynucleotide having a partial sequence thereof. The nucleic acid molecule according to the present invention can be used to detect sIgA in saliva.
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Inventors:
MINAGAWA HIROTAKA (JP)
HORII KATSUNORI (JP)
AKITOMI JOU (JP)
KANEKO NAOTO (JP)
WAGA IWAO (JP)
KUWAHARA MASAYASU (JP)
HORII KATSUNORI (JP)
AKITOMI JOU (JP)
KANEKO NAOTO (JP)
WAGA IWAO (JP)
KUWAHARA MASAYASU (JP)
Application Number:
PCT/JP2017/015934
Publication Date:
March 22, 2018
Filing Date:
April 20, 2017
Export Citation:
Assignee:
NEC SOLUTION INNOVATORS LTD (JP)
UNIV GUNMA NAT UNIV CORP (JP)
UNIV GUNMA NAT UNIV CORP (JP)
International Classes:
C12N15/09; C12N15/115; C12Q1/68; G01N33/53
Domestic Patent References:
| WO2015064223A1 | 2015-05-07 |
Foreign References:
| CN105738633A | 2016-07-06 | |||
| JP2016056136A | 2016-04-21 | |||
| JP2013040118A | 2013-02-28 |
Other References:
IMAIZUMI, Y. ET AL.: "Efficacy of Base- Modification on Target Binding of Small Molecule DNA Aptamers", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 135, no. 25, 2013, pages 9412 - 9419, XP055422191
MASAYASU KUWAHARA: "Kobunshi no Reprogramming Hi Tennen Bunshi o Donyu shita Kakusan Aptamer no Seise i", KOBUNSHI, vol. 63, no. 10, 2014, pages 730 - 731, XP009515048
TOKIKO ISOWA: "Relationship between Job Stressor, Burnout and Physical Health Problem in Nurses: A Study Using Questionnaire and Immunological Parameter", THE JAPANESE SOCIETY OF BEHAVIORAL MEDICINE, vol. 10, no. 1, 2003, pages 25 - 33, XP055476034
MASAYASU KUWAHARA ET AL.: "Modified nucleic acid aptamer selections using capillary electrophoresis", ELECTROPHORESIS LETTERS, vol. 59, no. 2, 2015, pages 88 - 90, XP009515310, DOI: 10.2198/electroph.59.88
NAOTO HONDA ET AL.: "Capillary Denki Eido Selection-ho ni yoru Kekkan Naihi Saibo Zoshoku Inshi Ketsugosei Enki Shushoku DNA Aptamer no Selection", 95TH ANNUAL MEETING OF THE CHEMICAL SOCIETY OF JAPAN IN SPRING (2015) KOEN YOKOSHU III, 11 March 2015 (2015-03-11), JP, pages 877, XP009513893
See also references of EP 3514237A4
MASAYASU KUWAHARA: "Kobunshi no Reprogramming Hi Tennen Bunshi o Donyu shita Kakusan Aptamer no Seise i", KOBUNSHI, vol. 63, no. 10, 2014, pages 730 - 731, XP009515048
TOKIKO ISOWA: "Relationship between Job Stressor, Burnout and Physical Health Problem in Nurses: A Study Using Questionnaire and Immunological Parameter", THE JAPANESE SOCIETY OF BEHAVIORAL MEDICINE, vol. 10, no. 1, 2003, pages 25 - 33, XP055476034
MASAYASU KUWAHARA ET AL.: "Modified nucleic acid aptamer selections using capillary electrophoresis", ELECTROPHORESIS LETTERS, vol. 59, no. 2, 2015, pages 88 - 90, XP009515310, DOI: 10.2198/electroph.59.88
NAOTO HONDA ET AL.: "Capillary Denki Eido Selection-ho ni yoru Kekkan Naihi Saibo Zoshoku Inshi Ketsugosei Enki Shushoku DNA Aptamer no Selection", 95TH ANNUAL MEETING OF THE CHEMICAL SOCIETY OF JAPAN IN SPRING (2015) KOEN YOKOSHU III, 11 March 2015 (2015-03-11), JP, pages 877, XP009513893
See also references of EP 3514237A4
Attorney, Agent or Firm:
TSUJIMARU Koichiro et al. (JP)
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