Title:
SECRETORY SIGNAL SEQUENCES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2003104400
Kind Code:
A3
Abstract:
The present invention provides polypeptide sequences which, when fused to a heterologous polypeptide, promote secretion of the resulting chimeric protein, and uses thereof.
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Inventors:
FASEL NICHOLAS (CH)
BEGHDADI-RAIS CAROLE (CH)
DESPONDS CHANTAL (CH)
COHEN GARY (US)
EISENBERG ROSELYN (US)
BEGHDADI-RAIS CAROLE (CH)
DESPONDS CHANTAL (CH)
COHEN GARY (US)
EISENBERG ROSELYN (US)
Application Number:
PCT/US2003/017661
Publication Date:
February 12, 2004
Filing Date:
June 06, 2003
Export Citation:
Assignee:
RMF DICTAGENE SA (CH)
UNIV PENNSYLVANIA (US)
FASEL NICHOLAS (CH)
BEGHDADI-RAIS CAROLE (CH)
DESPONDS CHANTAL (CH)
COHEN GARY (US)
EISENBERG ROSELYN (US)
UNIV PENNSYLVANIA (US)
FASEL NICHOLAS (CH)
BEGHDADI-RAIS CAROLE (CH)
DESPONDS CHANTAL (CH)
COHEN GARY (US)
EISENBERG ROSELYN (US)
International Classes:
C07K14/035; (IPC1-7): C12P21/02
Foreign References:
| US5814486A | 1998-09-29 |
Other References:
DEAN ET AL.: "Single amino acid substitution in gD of herpes simplex virus 1 confer resistance to gD-mediated interference and cause cell-type-dependent alterations in infectivity", VIROLOGY, vol. 199, 1994, pages 67 - 80, XP002970336
RUX ET AL.: "Functional region IV of glycoprotein D from herpes simplex virus modulates glycoprotein binding to the herpesvirus entry mediator", JOURNAL OF VIROLOGY, vol. 72, no. 9, September 1998 (1998-09-01), pages 7091 - 7098, XP002970337
WILLIS ET AL.: "Examination of the kinetics of herpes simplex virus glycoprotein D binding to the herpesvirus entry mediator, using surface plasmon resonance", JOURNAL OF VIROLOGY, vol. 72, no. 7, July 1998 (1998-07-01), pages 5937 - 5947, XP002970338
TERRY-ALLISON ET AL.: "Hve A (herpesvirus entry mediator A), a coreceptor for herpes simplex virus entry, also participates in virus-induced cell fusion", JOURNAL OF VIROLOGY, vol. 72, no. 7, July 1998 (1998-07-01), pages 5802 - 5810, XP002923344
HUBER ET AL.: "Herpes simplex virus with highly reduced gD levels can efficiently enter and spread between human keratinocytes", JOURNAL OF VIROLOGY, vol. 75, no. 21, November 2001 (2001-11-01), pages 10309 - 10318, XP002970339
JOHNSON ET AL.: "Soluble forms of herpes simplex virus glycoprotein D bind to a limited number of cell surface receptors and inhibit virus entry into cells", JOURNAL OF VIROLOGY, vol. 64, no. 6, June 1990 (1990-06-01), pages 2569 - 2576, XP000606350
RUX ET AL.: "Functional region IV of glycoprotein D from herpes simplex virus modulates glycoprotein binding to the herpesvirus entry mediator", JOURNAL OF VIROLOGY, vol. 72, no. 9, September 1998 (1998-09-01), pages 7091 - 7098, XP002970337
WILLIS ET AL.: "Examination of the kinetics of herpes simplex virus glycoprotein D binding to the herpesvirus entry mediator, using surface plasmon resonance", JOURNAL OF VIROLOGY, vol. 72, no. 7, July 1998 (1998-07-01), pages 5937 - 5947, XP002970338
TERRY-ALLISON ET AL.: "Hve A (herpesvirus entry mediator A), a coreceptor for herpes simplex virus entry, also participates in virus-induced cell fusion", JOURNAL OF VIROLOGY, vol. 72, no. 7, July 1998 (1998-07-01), pages 5802 - 5810, XP002923344
HUBER ET AL.: "Herpes simplex virus with highly reduced gD levels can efficiently enter and spread between human keratinocytes", JOURNAL OF VIROLOGY, vol. 75, no. 21, November 2001 (2001-11-01), pages 10309 - 10318, XP002970339
JOHNSON ET AL.: "Soluble forms of herpes simplex virus glycoprotein D bind to a limited number of cell surface receptors and inhibit virus entry into cells", JOURNAL OF VIROLOGY, vol. 64, no. 6, June 1990 (1990-06-01), pages 2569 - 2576, XP000606350
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