Title:
SELECTION AND USE OF UMBILICAL CORD CELL FRACTIONS SUITABLE FOR TRANSPLANTATION
Document Type and Number:
WIPO Patent Application WO/2018/211509
Kind Code:
A3
Abstract:
Methods of selecting umbilical cord blood units for ex-vivo expansion, separation of CD133+/CD34+ positive and uncultured CD133+/CD34+ negative fractions, methods for expanding the selected CD133+/CD34+ fraction, selection of expanded populations of CD133+/CD34+ cord blood cells for transplantation to subjects in need thereof and the therapeutic use of suitable selected, ex-vivo expanded CD133+/CD34+ and unselected CD133/CD34 negative cord blood fractions for transplantation in the clinical setting, for treatment of hematological malignancies are provided. The present invention also envisions kits comprising the expanded and unselected cord blood fractions.
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Inventors:
PELED TONY (IL)
HARATI DORIT (IL)
LANDAU EFRAT (IL)
HARATI DORIT (IL)
LANDAU EFRAT (IL)
Application Number:
PCT/IL2018/050537
Publication Date:
December 27, 2018
Filing Date:
May 16, 2018
Export Citation:
Assignee:
GAMIDA CELL LTD (IL)
International Classes:
A61K35/12; A61P7/00; A61P35/00; A61P35/02; C12N5/0789; C12Q1/06
Foreign References:
| US20120141434A1 | 2012-06-07 |
Other References:
SOUFIZOMORROD ET AL.: "Expansion of CD 133+ Umbilical Cord Blood Derived Hematopoietic Stem Cells on a Biocompatible Microwells", INT J HEMATOL ONCOL STEM CELL RES ., vol. 7, no. 1, 2013, pages 9 - 14, XP055557467
ANONYMOUS: "CD133 MicroBead Kit human - lyophilized", MILTENYI BIOTEC DATA SHEET, vol. 130-097-049, 2011, pages 1 - 4, XP009517726, Retrieved from the Internet [retrieved on 20180908]
HORWITZ ET AL.: "Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment", J CLIN INVEST., vol. 124, no. 7, 1 July 2014 (2014-07-01), pages 3121 - 3128, XP055557530
DE LALLA ET AL.: "High-frequency and adaptive-like dynamics of human CD 1 self-reactive T cells", EUR J IMMUNOL., vol. 41, no. 3, March 2011 (2011-03-01), pages 602 - 610, XP002668858
ANONYMOUS: "CD133 MicroBead Kit human - lyophilized", MILTENYI BIOTEC DATA SHEET, vol. 130-097-049, 2011, pages 1 - 4, XP009517726, Retrieved from the Internet
HORWITZ ET AL.: "Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment", J CLIN INVEST., vol. 124, no. 7, 1 July 2014 (2014-07-01), pages 3121 - 3128, XP055557530
DE LALLA ET AL.: "High-frequency and adaptive-like dynamics of human CD 1 self-reactive T cells", EUR J IMMUNOL., vol. 41, no. 3, March 2011 (2011-03-01), pages 602 - 610, XP002668858
Attorney, Agent or Firm:
EHRLICH, Gal et al. (IL)
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