Title:
SELECTIVE DISULFIDATION REAGENT USING NITROGEN-CONTAINING COMPOUND AND METHOD FOR PRODUCING DISULFIDE-CONTAINING COMPOUND
Document Type and Number:
WIPO Patent Application WO/2017/200109
Kind Code:
A1
Abstract:
[Problem] To provide a technique with which it is possible to selectively introduce a disulfide bond into two free thiol groups positioned within the molecule of an organic compound such as a peptide by a simple process in a short time and by a chemically stable method. [Solution] A nitrogen-containing compound represented by chemical formula 1 or a salt thereof. The symbols in chemical formula 1 are as defined in the specification.
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Inventors:
HAYASHI YOSHIO (JP)
TAGUCHI AKIHIRO (JP)
FUKUMOTO KENTARO (JP)
TAGUCHI AKIHIRO (JP)
FUKUMOTO KENTARO (JP)
Application Number:
PCT/JP2017/019086
Publication Date:
November 23, 2017
Filing Date:
May 22, 2017
Export Citation:
Assignee:
TOKYO UNIV OF PHARMACY & LIFE SCIENCES (JP)
KOKUSAN CHEMICAL CO LTD (JP)
KOKUSAN CHEMICAL CO LTD (JP)
International Classes:
C07D213/80; C07D401/12; C07K1/02
Domestic Patent References:
| WO2015050199A2 | 2015-04-09 |
Foreign References:
| JPS54128578A | 1979-10-05 |
Other References:
TAGUCHI, A. ET AL.: "3-Nitro-2-pyridinesulfenates as Efficient Solution- and Solid-Phase Disulfide Bond Forming Agents", CHEMISTRY EUR. J., vol. 23, no. 34, 16 June 2017 (2017-06-16), pages 8262 - 8267, XP055598365
ROSEN, 0. ET AL.: "Thiolysis of the 3-nitro-2-pyridinesulfenyl(Npys) protecting group", INT. J. PEPTIDE PROTEIN RES., vol. 35, no. 6, 1990, pages 545 - 549, XP000127614
MATSUEDA, R. ET AL.: "3-NITRO-2-PYRIDINESULFENYL(Npys)GROUP A Novel Selective Protecting Group Which Can Be Activated for Peptide Bond Formation", INT. J. PEPTIDE PROTEIN RES., vol. 16, no. 5, November 1980 (1980-11-01), pages 392 - 401, XP055275689
MATSUEDA, R. ET AL.: "Syntheses of 3-nitro-2-pyridinesulfenates", HETEROCYCLES, vol. 15, no. 8, 1980, pages 1089 - 1092
OLSEN, F. N. ET AL.: "Npys-Mediated Elimination Reactions of Alcohols and Thiols: A Facile Route to Dehydroalanine and Dehydrobutyrine Building Blocks", SYNLETT, vol. 26, no. 19, 6 November 2015 (2015-11-06), pages 2697 - 2701, XP055598368
MATSUEDA, R. ET AL. ET AL.: "3-NITRO-2-PYRIDINESULFENYL PROTECTING GROUP: ACTIVATABLE PROTECTING GROUP FOR PEPTIDE SYNTHESIS AND ENZYME MODIFICATION", PEPTIDE CHEMISTRY, vol. 18, 1980, pages 31 - 36
ROSEN, 0. ET AL.: "Thiolysis of the 3-nitro-2-pyridinesulfenyl(Npys) protecting group", INT. J. PEPTIDE PROTEIN RES., vol. 35, no. 6, 1990, pages 545 - 549, XP000127614
MATSUEDA, R. ET AL.: "3-NITRO-2-PYRIDINESULFENYL(Npys)GROUP A Novel Selective Protecting Group Which Can Be Activated for Peptide Bond Formation", INT. J. PEPTIDE PROTEIN RES., vol. 16, no. 5, November 1980 (1980-11-01), pages 392 - 401, XP055275689
MATSUEDA, R. ET AL.: "Syntheses of 3-nitro-2-pyridinesulfenates", HETEROCYCLES, vol. 15, no. 8, 1980, pages 1089 - 1092
OLSEN, F. N. ET AL.: "Npys-Mediated Elimination Reactions of Alcohols and Thiols: A Facile Route to Dehydroalanine and Dehydrobutyrine Building Blocks", SYNLETT, vol. 26, no. 19, 6 November 2015 (2015-11-06), pages 2697 - 2701, XP055598368
MATSUEDA, R. ET AL. ET AL.: "3-NITRO-2-PYRIDINESULFENYL PROTECTING GROUP: ACTIVATABLE PROTECTING GROUP FOR PEPTIDE SYNTHESIS AND ENZYME MODIFICATION", PEPTIDE CHEMISTRY, vol. 18, 1980, pages 31 - 36
Attorney, Agent or Firm:
HATTA & ASSOCIATES (JP)
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