Title:
SELECTIVE DOPAMINE D4 RECEPTOR AGONISTS FOR TREATMENT OF WORKING MEMORY DEFICITS
Document Type and Number:
WIPO Patent Application WO/2015/036972
Kind Code:
A3
Abstract:
Working memory deficits are treated and working memory is improved with a composition that comprises a therapeutically effective amount of one or more respective selective dopamine D4 receptor agonists and/or pharmaceutically acceptable analogs, salts or hydrates of the respective one or more selective dopamine D4 receptor agonists. This composition can be administered to a subject to improve the subject's working memory.
Inventors:
BHIDE PRADEEP G (US)
ZHU JINMIN (US)
BIEDERMAN JOSEPH (US)
SPENCER THOMAS J (US)
ZHU JINMIN (US)
BIEDERMAN JOSEPH (US)
SPENCER THOMAS J (US)
Application Number:
PCT/IB2014/064470
Publication Date:
August 06, 2015
Filing Date:
September 12, 2014
Export Citation:
Assignee:
UNIV FLORIDA STATE RES FOUND (US)
GEN HOSPITAL CORP (US)
GEN HOSPITAL CORP (US)
International Classes:
A61K31/496; A61K31/4545; A61K31/495; A61P25/00; A61P25/28
Foreign References:
| US8258139B2 | 2012-09-04 | |||
| EP2010505B1 | 2012-12-05 |
Other References:
BROWMAN ET AL.: "A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats", PHARMACOLOGY, BIOCHEMISTRY AND BEHAVIOR, vol. 82, no. 1, 2005, pages 148 - 155, XP027691024
FURTH ET AL.: "Dopamine, cognitive function, and gamma oscillations: role of D4 receptors", FRONTIERS IN CELLULAR NEUROSCIENCE, vol. 7, no. 102, 2 July 2013 (2013-07-02), pages 1 - 19, XP055217188
SANNA ET AL.: "Dopamine D2-like receptor agonists induce penile erection in male rats: differential role of D2, D3 and D4 receptors in the paraventricul ar nucleus of the hypothalamus", BEHAVIOURAL BRAIN RESEARCH, vol. 225, no. 1, 2011, pages 169 - 176, XP028284925
FURTH ET AL.: "Dopamine, cognitive function, and gamma oscillations: role of D4 receptors", FRONTIERS IN CELLULAR NEUROSCIENCE, vol. 7, no. 102, 2 July 2013 (2013-07-02), pages 1 - 19, XP055217188
SANNA ET AL.: "Dopamine D2-like receptor agonists induce penile erection in male rats: differential role of D2, D3 and D4 receptors in the paraventricul ar nucleus of the hypothalamus", BEHAVIOURAL BRAIN RESEARCH, vol. 225, no. 1, 2011, pages 169 - 176, XP028284925
Attorney, Agent or Firm:
JAGTIANI, Ajay (Suite 370Centreville, Virginia, US)
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