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Title:
SELECTIVE ELIMINATION OF SENESCENT CELLS BY FERROPTOSIS INDUCTION
Document Type and Number:
WIPO Patent Application WO/2023/133414
Kind Code:
A3
Abstract:
Disclosed are methods of treating diseases or disorders associated with cellular senescence as well as methods of inducing ferroptosis in senescent cells. The methods include administering a compound that induces ferroptosis.

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Inventors:
WILEY CHRISTOPHER (US)
Application Number:
PCT/US2023/060105
Publication Date:
August 31, 2023
Filing Date:
January 04, 2023
Export Citation:
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Assignee:
TUFTS COLLEGE (US)
International Classes:
G01N33/88; G01N33/569; A61K31/497; A61P35/00
Domestic Patent References:
WO2021247594A12021-12-09
Foreign References:
US20200138829A12020-05-07
US20190282660A12019-09-19
Other References:
GO ET AL.: "The Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis", TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 18, no. 5, 18 May 2021 (2021-05-18), pages 841 - 850, XP037563790, DOI: 10.1007/s13770-021-00346-z
Attorney, Agent or Firm:
KEATING, Thomas, J. (US)
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