Title:
SELECTIVE HISTONE DEACETYLASE INHIBITORS FOR THE TREATMENT OF HUMAN DISEASE
Document Type and Number:
WIPO Patent Application WO/2019/139921
Kind Code:
A1
Abstract:
Selective HDAC inhibitors, and pharmaceutical compositions that include the same, are described herein for the treatment of cancer, immunological diseases, inflammatory diseases, and neurological diseases.
Inventors:
GRINDROD SCOTT (US)
JUNG MIRA (US)
DRITSCHILO ANATOLY (US)
JUNG MIRA (US)
DRITSCHILO ANATOLY (US)
Application Number:
PCT/US2019/012770
Publication Date:
July 18, 2019
Filing Date:
January 08, 2019
Export Citation:
Assignee:
SHUTTLE PHARMACEUTICALS INC (US)
International Classes:
A61K31/433; C07C259/06; C07D285/04
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See also references of EP 3737376A4
REMISZEWSKI ET AL., J. MED CHEM., vol. 45, no. 4, 2002, pages 753 - 757
A.R. GENNARO ET AL.: "Remington: The Science and Practice of Pharmacy", 2000, LIPPINCOTT WILLIAMS & WILKINS, article "Pharmaceutical Manufacturing", pages: 669 - 1015
UMANA ET AL., NAT. BIOTECH, vol. 17, 1999, pages 176 - 180
JACQUES ET AL.: "Enantiomers, Racemates and Resolutions", 1981, WILEY INTERSCIENCE
E. L. ELIEL: "Stereochemistry of Carbon Compounds", 1962, MCGRAW-HILL
E. L. ELIELS. H. WILEN: "Stereochemistry of Organic Compounds", 1994, WILEY-INTERSCIENCE
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883
JONES ET AL., NATURE, vol. 321, 1986, pages 522 - 525
RIECHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 329
PRESTA, CURR. OP. STRUCT. BIOL., vol. 2, 1992, pages 593 - 596
YAMANE-OHNUKI ET AL., BIOTECHNOL. BIOENG., vol. 87, 2004, pages 614 - 622
SHIELDS ET AL., J. BIOL. CHEM., vol. 277, 2002, pages 26733 - 26740
TARENTINO ET AL., BIOCHEM., vol. 14, 1975, pages 5516 - 5523
WANG ET AL., CANCER IMMUNOL RES., vol. 2, 2014, pages 846 - 56
PAGE ET AL., ANN. REV. MED., vol. 65, 2014, pages 185 - 202
WEBER ET AL., J. CLIN. ONCOLOGY, vol. 31, 2013, pages 4311 - 4318
CAS , no. 1374853-91-4
FUERST, ONCOLOGY TIMES, vol. 36, 2014, pages 35 - 36
ROBERT ET AL., LANCET, vol. 384, 2014, pages 1109 - 17
THOMAS ET AL., EXP. OPIN. BIOL. THER., vol. 14, 2014, pages 1061 - 1064
BERGER ET AL., CLIN. CANCER RES., vol. 14, 2008, pages 3044 - 51
BRAHMER ET AL., J. CLIN. ONCOL., 2014, pages 32
MCDERMOTT, CANCER TREATMENT REV., vol. 40, 2014, pages 1056 - 64
MANSFIELD ET AL., BLOOD, vol. 90, 1997, pages 2020 - 2026
KREITMAN ET AL., CLIN CANCER RES., vol. 17, 2011, pages 6398 - 6405
"Handbook of Clinical Drug Data", 2002, MCGRAW-HILL
"Principles of Drug Action", 1990, CHURCHILL LIVINGSTON
See also references of EP 3737376A4
Attorney, Agent or Firm:
CHAI, Deping et al. (US)
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