Title:
SELECTIVE M4 RECEPTOR ANTAGONIST AND ITS MEDICAL USE
Document Type and Number:
WIPO Patent Application WO/2008/080290
Kind Code:
A1
Abstract:
Levo-nor-phencynonate and its nontoxic pharmaceutically acceptable salt as
selective M4 receptor antagonists, the composition comprising these compounds as
active components, and their uses in manufacture of medicaments for treating motor
functional disorders caused by Parkinson's syndrome, such as thrill, rigidity
etc. The structure of the compound is represented by formula IIa.
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Inventors:
ZHONG BOHUA (CN)
ZHENG JIANQUAN (CN)
WANG LIYUN (CN)
LIU HE (CN)
CHEN LANFU (CN)
LIU KELIANG (CN)
ZHENG JIANQUAN (CN)
WANG LIYUN (CN)
LIU HE (CN)
CHEN LANFU (CN)
LIU KELIANG (CN)
Application Number:
PCT/CN2007/003158
Publication Date:
July 10, 2008
Filing Date:
November 07, 2007
Export Citation:
Assignee:
INST PHARM & TOXICOLOGY AMMS (CN)
ZHONG BOHUA (CN)
ZHENG JIANQUAN (CN)
WANG LIYUN (CN)
LIU HE (CN)
CHEN LANFU (CN)
LIU KELIANG (CN)
ZHONG BOHUA (CN)
ZHENG JIANQUAN (CN)
WANG LIYUN (CN)
LIU HE (CN)
CHEN LANFU (CN)
LIU KELIANG (CN)
International Classes:
A61K31/439; C07D221/22; A61P25/16
Foreign References:
| CN1781904A | 2006-06-07 | |||
| CN1673209A | 2005-09-28 | |||
| CN1089838A | 1994-07-27 | |||
| US6028198A | 2000-02-22 | |||
| CN97125424A | ||||
| GB2297255A | 1996-07-31 | |||
| ES549796A0 | 1986-03-16 | |||
| CN1104881A | 1995-07-12 |
Other References:
DATABASE CA [online] WANG L.-Y. ET AL.: "Comparative study on pharmacological effects of DM-phenylcynonate hydrochloride and its optical isomers", XP008110372, Database accession no. (144:454)
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (Vantone New World Plaza2 Fuchengmenwai St, Beijing 7, CN)
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