Title:
SELECTIVE MODULATORS OF PEROXISOME PROLIFERATOR ACSELECTIVE MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR-GAMMA, AND METHODS FOR THE USE THTIVATED RECEPTOR-GAMMA, AND METHODS FOR THE USE THEREOF EREOF
Document Type and Number:
WIPO Patent Application WO1996033724
Kind Code:
A3
Abstract:
In accordance with the present invention, there are provided a class of compounds which are capable of selectively modulating processes mediated by peroxisome proliferator activated receptor-gamma (PPAR-gamma). The identification of such compounds makes possible the selective intervention in PPAR-gamma mediated pathways, without exerting inadvertent effects on pathways mediated by other PPAR isoforms.
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Inventors:
EVANS RONALD M (US)
FORMAN BARRY M (US)
FORMAN BARRY M (US)
Application Number:
PCT/US1996/005465
Publication Date:
January 30, 1997
Filing Date:
April 18, 1996
Export Citation:
Assignee:
SALK INST FOR BIOLOGICAL STUDI (US)
EVANS ROLAND M (US)
FORMAN BARRY M (US)
EVANS ROLAND M (US)
FORMAN BARRY M (US)
International Classes:
A61K31/557; G01N33/15; A61K31/5575; A61K45/00; A61P3/04; A61P3/06; A61P3/08; C12Q1/68; (IPC1-7): A61K31/557
Other References:
S.A. KLIEWER ET AL.: "Differential expression and activation of a family of murine peroxisome proliferator-activated receptors", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 91, July 1994 (1994-07-01), WASHINGTON US, pages 7355 - 7359, XP002007699
M.E. GREENE ET AL.: "Isolation of the human peroxisome proliferator activated receptor gamma cDNA", GENE EXPRESSION, vol. 4, 1995, pages 281 - 299, XP000057446
J.M.LEHMANN ET AL.: "An antidiabetic thiazolidinone is a high affinity ligand for peroxisome prolifirator-activated receptor", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 22, 2 June 1995 (1995-06-02), MD US, pages 12953 - 12956, XP002007698
K. YU ET AL.: "Differential activation of peroxisome proliferator-activated receptors by eicosanoids", J. BIOL. CHEM., vol. 270, no. 41, 13 October 1995 (1995-10-13), pages 23975 - 23983, XP002008288
S.A. KLIEWER ET AL.: "A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentation", CELL, vol. 83, 1 December 1995 (1995-12-01), pages 813 - 819, XP000575884
B.M. FORMAN ET AL.: "15-DEOXY-DELTA12,14-PROSTAGLANDING J2 IS A LIGAND FOR THE ADIPOCYTE DETERMINATION FACTOR PPAR GAMMA", CELL, vol. 83, 1 December 1995 (1995-12-01), pages 803 - 812, XP000575803
M.E. GREENE ET AL.: "Isolation of the human peroxisome proliferator activated receptor gamma cDNA", GENE EXPRESSION, vol. 4, 1995, pages 281 - 299, XP000057446
J.M.LEHMANN ET AL.: "An antidiabetic thiazolidinone is a high affinity ligand for peroxisome prolifirator-activated receptor", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 22, 2 June 1995 (1995-06-02), MD US, pages 12953 - 12956, XP002007698
K. YU ET AL.: "Differential activation of peroxisome proliferator-activated receptors by eicosanoids", J. BIOL. CHEM., vol. 270, no. 41, 13 October 1995 (1995-10-13), pages 23975 - 23983, XP002008288
S.A. KLIEWER ET AL.: "A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentation", CELL, vol. 83, 1 December 1995 (1995-12-01), pages 813 - 819, XP000575884
B.M. FORMAN ET AL.: "15-DEOXY-DELTA12,14-PROSTAGLANDING J2 IS A LIGAND FOR THE ADIPOCYTE DETERMINATION FACTOR PPAR GAMMA", CELL, vol. 83, 1 December 1995 (1995-12-01), pages 803 - 812, XP000575803
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