SELECTIVE N-SULFONYLATION OF 2-AMINO TRIFLUOROALKYL SUBSTITUTED ALCOHOLS

Title:

SELECTIVE N-SULFONYLATION OF 2-AMINO TRIFLUOROALKYL SUBSTITUTED ALCOHOLS

Document Type and Number:

WIPO Patent Application WO2007098030

Kind Code:

A8

Abstract:

Processes for the preparation of trifluoroalkyl substituted N-(2-hydroxyalkyl) heteroarene- and benzenesulphonamide derivatives of formula (I) or formula (II) (wherein the variables are as defined in the claims) are provided which comprises reacting a trifluoroalkyl substituted amino alcohol, a sulphonyl chloride and a base/solvent system selected from the group consisting of (a) 4-methylmorpholine/isopropyl acetate, (b) Hünig's base/tetrahydrofuran, (c) 4-methylmorpholine/acetonitrile, (d) 4-methylmorpholine/propionitrile and (e) 4-methylmorpholin/ftoluene. Formulae (I) and (II).

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Inventors:

CHAN ANITA WAI-YIN (US)
REN JIANXIN (US)
GHOSH MOUSUMI (US)
RAVEENDRANATH PANOLIL (US)

Application Number:

PCT/US2007/004091

Publication Date:

October 25, 2007

Filing Date:

February 15, 2007

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Assignee:

WYETH CORP (US)
CHAN ANITA WAI-YIN (US)
REN JIANXIN (US)
GHOSH MOUSUMI (US)
RAVEENDRANATH PANOLIL (US)

International Classes:

C07D333/34; C07C303/38; C07C311/17

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