Title:
SELECTIVE PARP1 INHIBITOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/088408
Kind Code:
A1
Abstract:
A selective PARP1 inhibitor and an application thereof. Provided are a compound represented by general formula (I-A), and a stereoisomer, a pharmaceutically acceptable salt or a deuterated compound thereof. Also provided are a pharmaceutical composition comprising the compound or the stereoisomer thereof, and an application of the compound and the pharmaceutical composition in preparation of anti-tumor drugs.
Inventors:
ZHANG JING (CN)
WEI YONGGANG (CN)
SUN YI (CN)
WEI YONGGANG (CN)
SUN YI (CN)
Application Number:
PCT/CN2022/132782
Publication Date:
May 25, 2023
Filing Date:
November 18, 2022
Export Citation:
Assignee:
CHENGDU BAIYU PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D471/04; A61K31/4375; A61K31/498; A61P35/00; C07D401/12; C07D401/14; C07D487/04; C07D491/14
Domestic Patent References:
| WO2022225934A1 | 2022-10-27 | |||
| WO2022222995A1 | 2022-10-27 | |||
| WO2009053373A1 | 2009-04-30 | |||
| WO2022228387A1 | 2022-11-03 | |||
| WO2022223025A1 | 2022-10-27 | |||
| WO2021013735A1 | 2021-01-28 |
Other References:
REN JUNKANG, QUAN XU, LIU YING, LI JIANI, ZHANG XIAOYU, LI ZHIYU, ZHANG XIAOMENG: "Synthesis and in vitro biological evaluation of 3-ethyl-1,5-naphthyridin-2(1H)-one derivatives as potent PARP-1 selective inhibitors and PARP-1 DNA trappers", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 78, 31 October 2022 (2022-10-31), Amsterdam NL , pages 129046, XP093067861, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2022.129046
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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