Title:
SELECTIVE PARP1 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2024/046366
Kind Code:
A1
Abstract:
The present invention provides a selective PARP1 inhibitor. Specifically, the present invention provides a compound or a pharmaceutically acceptable salt or solvate thereof, wherein the compound is represented by formula A, and the groups are as defined herein. The present invention also provides a preparation method for the compound and a use of the compound.
Inventors:
WANG NENGHUI (CN)
Application Number:
PCT/CN2023/115820
Publication Date:
March 07, 2024
Filing Date:
August 30, 2023
Export Citation:
Assignee:
ZHEJIANG WENDA PHARMA TECH LTD (CN)
International Classes:
C07D401/12; A61K31/4375; A61P35/00
Domestic Patent References:
| WO2021013735A1 | 2021-01-28 | |||
| WO2009053373A1 | 2009-04-30 | |||
| WO2021260092A1 | 2021-12-30 | |||
| WO2022222921A1 | 2022-10-27 | |||
| WO2022222966A1 | 2022-10-27 | |||
| WO2022222995A1 | 2022-10-27 | |||
| WO2022228387A1 | 2022-11-03 | |||
| WO2023109521A1 | 2023-06-22 | |||
| WO2023138541A1 | 2023-07-27 | |||
| WO2023146957A1 | 2023-08-03 |
Foreign References:
| CN114144413A | 2022-03-04 | |||
| CN114206853A | 2022-03-18 | |||
| CN115232154A | 2022-10-25 | |||
| CN115677688A | 2023-02-03 | |||
| CN116143776A | 2023-05-23 | |||
| CN116496271A | 2023-07-28 | |||
| CN116535401A | 2023-08-04 |
Other References:
JOHANNES JEFFREY W., BALAZS AMBER, BARRATT DEREK, BISTA MICHAL, CHUBA MATTHEW D., COSULICH SABINA, CRITCHLOW SUSAN E., DEGORCE SÉB: "Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}- N -methylpyridine-2-carboxamide (AZD5305): A PARP1–DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 64, no. 19, 14 October 2021 (2021-10-14), US , pages 14498 - 14512, XP093028792, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.1c01012
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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