Title:
SELECTIVELY POLYMERIZABLE COMPOSITIONS AND METHODS OF USE IN VIVO
Document Type and Number:
WIPO Patent Application WO/2014/004936
Kind Code:
A8
Abstract:
Otologic materials and methods are provided. For example, a cell-adhesive, biodegrable hydrogel scaffold loaded with time-released drugs for repairing chronic tympanic membrane perforations is disclosed, methods of making same and administering same are provided. This hydrogel may promote vascular in-growth and pithelial cell growth of the tympanic membrane with the purpose of closing the perforation and providing a barrier between the external and middle ear. The hydrogel is initially a liquid polymer that only gels upon exposure to specific conditions, such as exposure to light. This scaffold may simultaneously induce repair of the tympanic membrane while preventing or alleviating middle ear infection, thus filling a void in current tympanic membrane perforation therapies.
Inventors:
RANNEY JESSE (US)
HORN-RANNEY ELAINE (US)
KHOSHAKHLAGH PARASTOO (US)
MOORE MICHAEL (US)
HORN-RANNEY ELAINE (US)
KHOSHAKHLAGH PARASTOO (US)
MOORE MICHAEL (US)
Application Number:
PCT/US2013/048385
Publication Date:
January 30, 2014
Filing Date:
June 28, 2013
Export Citation:
Assignee:
UNIV TULANE (US)
RANNEY JESSE (US)
RANNEY JESSE (US)
International Classes:
A61L27/56; A61L27/14; A61L27/20; A61L27/52
Attorney, Agent or Firm:
VASSILOVSKI, Edna (5401 Netherby Lane Suite 102, North Charleston SC, US)
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