Title:
SELENOPSAMMAPLIN A AND DERIVATIVE THEREOF, PREPARATION METHOD THEREFOR, AND COMPOSITION FOR PREVENTING AND TREATING CANCER, CONTAINING SAME AS ACTIVE INGREDIENTS
Document Type and Number:
WIPO Patent Application WO/2019/093699
Kind Code:
A1
Abstract:
The present invention relates to: novel selenopsammaplin A and a derivative thereof, which have anticancer activity; a preparation method therefor; and a pharmaceutical composition containing the same as active ingredients and, more specifically, to: a novel compound selenopsammaplin A and a derivative thereof which exhibit more excellent anticancer activity since a disulfide moiety thereof is substituted with diselenide according to research on the structural activity of psammaplin A, which is known to have an effect of inhibiting the growth of cancer cells; a preparation method therefor; and a composition for preventing or treating cancer, containing the same as active ingredients. According to the present invention, the novel selenopsammaplin A and the derivative thereof exhibit excellent anticancer activity on various human cancer cell lines so as to be expected to be effectively usable in a pharmaceutical composition for cancer prevention and treatment.
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Inventors:
PARK HYEUNG GEUN (KR)
LEE SANG KOOK (KR)
HAN HAE JU (KR)
BYUN WOONG SUB (KR)
LEE SANG KOOK (KR)
HAN HAE JU (KR)
BYUN WOONG SUB (KR)
Application Number:
PCT/KR2018/012826
Publication Date:
May 16, 2019
Filing Date:
October 26, 2018
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
C07C391/00; A61K31/4035
Foreign References:
| KR20140141904A | 2014-12-11 | |||
| US5608110A | 1997-03-04 | |||
| US20090124667A1 | 2009-05-14 | |||
| KR20160125989A | 2016-11-01 |
Other References:
YUE, D. ET AL.: "Influence of Reduction-sensitive Diselenide Bonds and Disulfide Bonds on Oligoethylenimine Conjugates for Gene Delivery", J. MATER. CHEM. B, vol. 2, no. 24, 2014, pages 7210 - 7221, XP055198192, DOI: doi:10.1039/C4TB00757C
See also references of EP 3708563A4
HONG S ET AL., EUR. J. MED. CHEM., vol. 96, 2017, pages 218
LEE SK ET AL., CHEM BIOL INTERACT, vol. 115, 2008, pages 215 - 28
LEE ET AL., CHEM BIOL INTERACT, vol. 115, 1998, pages 215 - 28
See also references of EP 3708563A4
HONG S ET AL., EUR. J. MED. CHEM., vol. 96, 2017, pages 218
LEE SK ET AL., CHEM BIOL INTERACT, vol. 115, 2008, pages 215 - 28
LEE ET AL., CHEM BIOL INTERACT, vol. 115, 1998, pages 215 - 28
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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