Title:
SELF-ASSEMBLED PEPTIDE-AMPHIPHILES & SELF-ASSEMBLED PEPTIDE NANOFIBER NETWORKS PRESENTING MULTIPLE SIGNALS
Document Type and Number:
WIPO Patent Application WO2004106359
Kind Code:
A3
Abstract:
The present invention provides a mixture of self-assembling peptide-amphiphiles with complementary charges whose design and function is patterned after proteins having biological functions. The oppositely charged peptide amphiphiles may be self-assembled by combining them in a charge equivalent ratio. Variations of structural peptide sequences in the oppositely charged peptide-amphiphiles enable the assembled nanofibers to exhibit two or more biologically relevant signals.
More Like This:
Inventors:
STUPP SAMUEL I (US)
HARTGERINK JEFFREY D (US)
NIECE KRISTA L (US)
HARTGERINK JEFFREY D (US)
NIECE KRISTA L (US)
Application Number:
PCT/US2003/029581
Publication Date:
February 16, 2006
Filing Date:
September 23, 2003
Export Citation:
Assignee:
UNIV NORTHWESTERN (US)
STUPP SAMUEL I (US)
HARTGERINK JEFFREY D (US)
NIECE KRISTA L (US)
STUPP SAMUEL I (US)
HARTGERINK JEFFREY D (US)
NIECE KRISTA L (US)
International Classes:
A61K38/08; A61K47/48; C07K7/06; C07K7/08; C07K14/78; A61K38/00; C07K; (IPC1-7): A61K38/00
Other References:
"Biofunctionalization of Surfaces with Peptide Amphilphiles", AVS 46.SUP.THE INTERNATIONAL SYMPOSIUM, vol. BI-WEM7, 27 October 1999 (1999-10-27)
NARUSAWA ET AL: "Hydrophilicity of Polar and Apolar Domains of Amphiphiles", J. COLLOID INTERFACE SCI., vol. 229, no. 2, 15 September 2000 (2000-09-15), pages 375 - 390, XP002995114
NARUSAWA ET AL: "Hydrophilicity of Polar and Apolar Domains of Amphiphiles", J. COLLOID INTERFACE SCI., vol. 229, no. 2, 15 September 2000 (2000-09-15), pages 375 - 390, XP002995114
Download PDF:
Previous Patent: TARGET-ORIENTED CHEMOTHERAPY FOR TREATING TUMORS OF THE SEXUAL ORGANS
Next Patent: VIRAL VECTORS WITH IMPROVED PROPERTIES
Next Patent: VIRAL VECTORS WITH IMPROVED PROPERTIES