Title:
SELF-ASSEMBLING UNDERWATER ADHESIVES
Document Type and Number:
WIPO Patent Application WO/2015/126480
Kind Code:
A3
Abstract:
Compositions, methods, and kits are provided which involve novel fusion protein- based adhesives for use in medical and marine applications. In some aspects, the novel fusion proteins comprise an adhesive domain (e.g., derived from an adhesive protein of a marine organism) and an amyloid domain (e.g., derived from a bacterial amyloid protein). Also provided are copolymers and fibers of the fusion proteins.
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Inventors:
LU TIMOTHY KUAN-TA (US)
ZHONG CHAO (US)
ZHONG CHAO (US)
Application Number:
PCT/US2014/065470
Publication Date:
December 17, 2015
Filing Date:
November 13, 2014
Export Citation:
Assignee:
MASSACHUSETTS INST TECHNOLOGY (US)
International Classes:
C07K14/245; C12N15/62; C07K14/435; C07K14/78
Domestic Patent References:
| WO2012166906A1 | 2012-12-06 | |||
| WO2008022774A2 | 2008-02-28 | |||
| WO2008150101A2 | 2008-12-11 |
Other References:
CHAO ZHONG ET AL: "Strong underwater adhesives made by self-assembling multi-protein nanofibres", NATURE NANOTECHNOLOGY, vol. 9, no. 10, 21 September 2014 (2014-09-21), pages 858 - 866, XP055208249, ISSN: 1748-3387, DOI: 10.1038/nnano.2014.199
CHAO ZHONG ET AL: "Biologically Inspired Engineering of Self-assembling Underwater Adhesives with Synthetic Biology", SOCIETY FOR BIOMATERIALS ANNUAL MEETING AND EXPOSITION 2014 - TRANSACTIONS OF THE 38TH ANNUAL MEETING, 16 April 2014 (2014-04-16), XP055208302
CHAO ZHONG ET AL: "Biologically Inspired Engineering of Self-assembling Underwater Adhesives with Synthetic Biology", SOCIETY FOR BIOMATERIALS ANNUAL MEETING AND EXPOSITION 2014 - TRANSACTIONS OF THE 38TH ANNUAL MEETING, 16 April 2014 (2014-04-16), XP055208302
Attorney, Agent or Firm:
BAKER, Hunter, C. (Greenfield & Sacks P.C.,600 Atlantic Avenu, Boston MA, US)
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