Title:
SELF DEGRADATION-TYPE CDK9 INHIBITOR PRODRUG AND LIPOSOME ENCAPSULATING SAME
Document Type and Number:
WIPO Patent Application WO/2023/027032
Kind Code:
A1
Abstract:
Provided are a self degradation-type CDK9 inhibitor prodrug and a liposome encapsulating same. The present invention pertains to a compound represented by formula (1), or a pharmaceutically acceptable salt thereof [in the formula, R1 represents an optionally substituted C1-6 alkyl group, R2 and R3 are identical or different from each other, and each independently represent a hydrogen atom or an optionally substituted C1-6 alkyl group, X represents CH2 or an oxygen atom, n represents 1 or 2, p represents 0, 1, or 2, q represents 1 or 2, r represents 0, 1, or 2, and, when X represents an oxygen atom, q represents 2].
Inventors:
KAMIOKA SEIJI (JP)
SHIMADA NAOAKI (JP)
MATSUOKA MAKOTO (JP)
BAN HITOSHI (JP)
SHIMADA NAOAKI (JP)
MATSUOKA MAKOTO (JP)
BAN HITOSHI (JP)
Application Number:
PCT/JP2022/031584
Publication Date:
March 02, 2023
Filing Date:
August 22, 2022
Export Citation:
Assignee:
SUMITOMO PHARMA CO LTD (JP)
International Classes:
C07D405/14; A61K9/127; A61K31/4545; A61K31/5377; A61K45/00; A61K47/24; A61K47/28; A61K47/32; A61K47/34; A61P35/00; A61P35/02; A61P43/00; C07D413/14
Domestic Patent References:
| WO2018094275A1 | 2018-05-24 | |||
| WO2019224790A2 | 2019-11-28 | |||
| WO2021172359A1 | 2021-09-02 | |||
| WO2016187316A1 | 2016-11-24 | |||
| WO2018094275A1 | 2018-05-24 | |||
| WO2019059344A1 | 2019-03-28 |
Foreign References:
| CN106866733A | 2017-06-20 | |||
| US6352996B1 | 2002-03-05 | |||
| JP2021135603A | 2021-09-13 |
Other References:
SUOPING ZHAI ET AL., THE ANNALS OF PHARMACOTHERAPY, vol. 36, 2002, pages 905 - 911
ATIAR M. RAHMAN ET AL., INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 2, no. 4, 2007, pages 567 - 583
YECHEZKEL (CHEZY) BARENHOLZ, JOURNAL OF CONTROLLED RELEASE, vol. 160, 2012, pages 117 - 134
XIAOJUAN YANG ET AL., INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 365, 2009, pages 170 - 174
THEODORA W. GREENEPETER G.M. WUTS: "Greene's Protective Groups in Organic Synthesis", 2014, JOHN WILEY & SONS, INC.
ATIAR M. RAHMAN ET AL., INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 2, no. 4, 2007, pages 567 - 583
YECHEZKEL (CHEZY) BARENHOLZ, JOURNAL OF CONTROLLED RELEASE, vol. 160, 2012, pages 117 - 134
XIAOJUAN YANG ET AL., INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 365, 2009, pages 170 - 174
THEODORA W. GREENEPETER G.M. WUTS: "Greene's Protective Groups in Organic Synthesis", 2014, JOHN WILEY & SONS, INC.
Attorney, Agent or Firm:
YAMAMOTO, Shusaku et al. (JP)
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