Title:
SEMAGLUTIDE SOLUBLE MICRONEEDLE COMPOSITION AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/159702
Kind Code:
A1
Abstract:
A semaglutide soluble microneedle composition and a preparation method therefor. The soluble microneedle composition comprises a needle body material and a base material. The needle body material comprises semaglutide and hyaluronidase, and the mass ratio of semaglutide to hyaluronidase is (0.05-172):1. The semaglutide and the hyaluronidase are combined to prepare the soluble microneedle composition, so that the semaglutide can be better promoted to diffuse into the systemic circulation. Compared with a semaglutide oral tablet, the soluble microneedle composition has the advantages that the blood sugar regulating effect is improved by nearly 40 times, the bioavailability of semaglutide is improved, and the dosage and the medication cost of the hypoglycemic drug are reduced. Moreover, a soluble microneedle technology is adopted, so that no pain is caused during use, and the discomfort of users is reduced.
Inventors:
WU CHUANBIN (CN)
CHEN HANGPING (CN)
LI FENG (CN)
FENG DISANG (CN)
YANG BEIBEI (CN)
ZHAO ZHIMING (CN)
CHEN HANGPING (CN)
LI FENG (CN)
FENG DISANG (CN)
YANG BEIBEI (CN)
ZHAO ZHIMING (CN)
Application Number:
PCT/CN2022/081495
Publication Date:
August 31, 2023
Filing Date:
March 17, 2022
Export Citation:
Assignee:
GUANGZHOU NOVAKEN PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K9/00; A61K38/26; A61K47/32; A61K47/38; A61K47/42; A61M37/00; A61P3/10
Domestic Patent References:
| WO2021196546A1 | 2021-10-07 | |||
| WO2020234384A1 | 2020-11-26 | |||
| WO2021089752A1 | 2021-05-14 |
Foreign References:
| CN112274633A | 2021-01-29 | |||
| CN112741897A | 2021-05-04 | |||
| US20080269666A1 | 2008-10-30 |
Attorney, Agent or Firm:
JIAQUAN IP LAW (CN)
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