Title:
SEMI-SYNTHETIC CONVERSION OF PACLITAXEL TO DOCETAXEL
Document Type and Number:
WIPO Patent Application WO2006004898
Kind Code:
A3
Abstract:
A process is provided for the semi-synthesis of taxane derivatives useful in the preparation of docetaxel, in particular, the semi-synthesis of protected taxane derivatives in a one pot reaction of protecting the C-2', C-7 and C-10 and introducing a t-Boc group at the nitrogen of the amide group at the C-3' position in paclitaxel and subsequently conversion to docetaxel, and derivatives used therein.
Inventors:
NAIDU RAGINA (CA)
FOO SAMUEL SIANG KIANG (CA)
XUE BAOYU (CA)
FAN BO (CA)
FOO SAMUEL SIANG KIANG (CA)
XUE BAOYU (CA)
FAN BO (CA)
Application Number:
PCT/US2005/023224
Publication Date:
March 09, 2006
Filing Date:
June 29, 2005
Export Citation:
Assignee:
PHYTOGEN LIFE SCIENCES INC (CA)
PHYTOGEN INC (US)
NAIDU RAGINA (CA)
FOO SAMUEL SIANG KIANG (CA)
XUE BAOYU (CA)
FAN BO (CA)
PHYTOGEN INC (US)
NAIDU RAGINA (CA)
FOO SAMUEL SIANG KIANG (CA)
XUE BAOYU (CA)
FAN BO (CA)
International Classes:
C07D305/14
Foreign References:
US5703247A | 1997-12-30 |
Other References:
JAGTAP P G ET AL: "A Facile N-Debenzoylation of Paclitaxel: Conversion of Paclitaxel to Docetaxel", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 40, no. 2, 8 January 1999 (1999-01-08), pages 189 - 192, XP004152507, ISSN: 0040-4039
KINGSTON D G I ET AL: "SYNTHESIS AND BIOLOGICAL EVALUATION OF 2-ACYL ANALOGUES OF PACLITAXEL (TAXOL)", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 41, no. 19, 1998, pages 3715 - 3726, XP000952731, ISSN: 0022-2623
KINGSTON D G I ET AL: "SYNTHESIS AND BIOLOGICAL EVALUATION OF 2-ACYL ANALOGUES OF PACLITAXEL (TAXOL)", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 41, no. 19, 1998, pages 3715 - 3726, XP000952731, ISSN: 0022-2623
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