Title:
SENESCENCE CONTROL COMPOSITION CONTAINING EXTRACELLULAR MATRIX COMPONENTS, AND SENESCENCE CONTROL METHOD FOR SENESCENT CELLS USING SAME
Document Type and Number:
WIPO Patent Application WO/2010/013934
Kind Code:
A2
Abstract:
The present invention relates to a senescence control composition containing extracellular matrix components, and a senescence control method for senescent cells. The senescence control composition and method of the present invention exhibited an effect in recovering the biological function of senescent cells, and enhanced the expression of integrin alpha v, a membrane protein the amount of which was decreased during senescence, in a senescent cell recovered by a young extracellular matrix. However, when the expression of integrin alpha v was artificially reduced by use of siRNA and antibody, a senescent cell was not recovered by an extracellular matrix extracted from a young cell.
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Inventors:
PARK, Sang Chul (206dong 101ho, Heights Village369-16 Gungnae-dong, Bundang-g, Seongnam-si Gyeonggi-do 463-470, 463-070, KR)
박상철 (경기도 성남시 분당구 궁내동 369-16 하이츠빌리지 206동 101호, 463-070 Gyeonggi-do, 463-070, KR)
CHO, Kyung A (101dong 307ho, Daewoo Mirae Sarang Apt.Dangsandong2-ga, Yeongdeungpo-gu, Seoul 150-935, 150-935, KR)
조경아 (서울시 영등포구 당산동2가 대우미래사랑아파트 101동 307호, 150-935 Seoul, 150-935, KR)
박상철 (경기도 성남시 분당구 궁내동 369-16 하이츠빌리지 206동 101호, 463-070 Gyeonggi-do, 463-070, KR)
CHO, Kyung A (101dong 307ho, Daewoo Mirae Sarang Apt.Dangsandong2-ga, Yeongdeungpo-gu, Seoul 150-935, 150-935, KR)
조경아 (서울시 영등포구 당산동2가 대우미래사랑아파트 101동 307호, 150-935 Seoul, 150-935, KR)
Application Number:
KR2009/004212
Publication Date:
February 04, 2010
Filing Date:
July 29, 2009
Export Citation:
Assignee:
SNU R&DB FOUNDATION (San 56-1, Sillim-dongGwanak-gu, Seoul 151-015, 151-015, KR)
서울대학교산학협력단 (서울시 관악구 신림동 산 56-1, 151-015 Seoul, 151-015, KR)
PARK, Sang Chul (206dong 101ho, Heights Village369-16 Gungnae-dong, Bundang-g, Seongnam-si Gyeonggi-do 463-470, 463-070, KR)
박상철 (경기도 성남시 분당구 궁내동 369-16 하이츠빌리지 206동 101호, 463-070 Gyeonggi-do, 463-070, KR)
CHO, Kyung A (101dong 307ho, Daewoo Mirae Sarang Apt.Dangsandong2-ga, Yeongdeungpo-gu, Seoul 150-935, 150-935, KR)
서울대학교산학협력단 (서울시 관악구 신림동 산 56-1, 151-015 Seoul, 151-015, KR)
PARK, Sang Chul (206dong 101ho, Heights Village369-16 Gungnae-dong, Bundang-g, Seongnam-si Gyeonggi-do 463-470, 463-070, KR)
박상철 (경기도 성남시 분당구 궁내동 369-16 하이츠빌리지 206동 101호, 463-070 Gyeonggi-do, 463-070, KR)
CHO, Kyung A (101dong 307ho, Daewoo Mirae Sarang Apt.Dangsandong2-ga, Yeongdeungpo-gu, Seoul 150-935, 150-935, KR)
International Classes:
A61K35/12
Attorney, Agent or Firm:
SESHIN PATENT & LAW FIRM (#207 World Meridian Venture Center II, 426-5 Gasan-dong Geumcheon-gu, Seoul 153-781, 153-781, KR)
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