SENSITIVE SUBSTANCE ENCAPSULATION

Title:

SENSITIVE SUBSTANCE ENCAPSULATION

Document Type and Number:

WIPO Patent Application WO/2001/045835

Kind Code:

A1

Abstract:

A process for stabilizing a sensitive substance; (a) plating a sensitive substance onto a solid carrier under a controlled atmosphere to reduce loss of the sensitive substance; (b) encapsulating the plated material under controlled atmosphere and airflow to reduce volatilization during the process and stabilize the sensitive substance.

Inventors:

PACIFICO CARL J (US)
WU WEN-HSIN (US)
FRALEY MARTA (US)

Application Number:

PCT/US2000/033673

Publication Date:

June 28, 2001

Filing Date:

December 13, 2000

Export Citation:

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Assignee:

BALCHEM CORP (US)
PACIFICO CARL J (US)
WU WEN HSIN (US)
FRALEY MARTA (US)

International Classes:

A23L1/00; A23L27/00; A23L27/12; A23L29/00; A61K9/50; A61K35/74; A61K38/43; B01J2/00; B01J13/02; (IPC1-7): B01J13/02; A23L1/22; A23P1/04; C12N11/12; C12N11/14

Domestic Patent References:

WO1996009773A1

1996-04-04

Foreign References:

GB825480A	1959-12-16
GB1318799A	1973-05-31

Other References:

PATENT ABSTRACTS OF JAPAN vol. 004, no. 054 (C - 008) 23 April 1980 (1980-04-23)
See also references of EP 1242174A1

Attorney, Agent or Firm:

Baron, Ronald J. (NY, US)

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Claims:

WHAT IS CLAIMED IS:

1.	A method of encapsulating a sensitive material comprising: plating the sensitive material onto a solid carrier, in an atmosphere inert to the sensitive material, to form a plated material; and encapsulating the plated material.

2.	The method of claim 1 wherein the atmosphere inert to the sensitive material is nitrogen, carbon dioxide, or helium.

3.	The method of claim 1 wherein the solid carrier is chilled prior to plating with the sensitive material.

4.	The method of claim 3 wherein the solid carrier is chilled by liquid nitrogen.

5.	The method of claim 1 wherein the solid carrier is porous or semi porous.

6.	The method of claim 5 wherein the solid carrier is maltodextrin, silicon dioxide, starches and starch derivatives, gums, or hydrocolloids.

7.	The method of claim 6 wherein the encapsulation occurs in an atmosphere inert to the sensitive material.

8.	The method of claim 7 wherein the atmosphere inert to the sensitive material is oxygenfree.

9.	The method of claim 7 wherein the atmosphere inert to the sensitive material is nitrogen, carbon dioxide, or helium.

10.	The method of claim 1 wherein the sensitive material has a boiling point of between about 40°F and 250°F.

11.	The method of claim 1 wherein the atmosphere inert to the sensitive material is oxygenfree.

12.	The method of claim 1 wherein the sensitive material is sprayed onto the solid carrier.

13.	The method of claim 1 further comprising encapsulating the plated material with a melted encapsulant.

14.	The method of claim 1 wherein the percentage of encapsulant in the resulting encapsulated particles is between about 10 to about 90%,.

15.	The method of claim 14 wherein the percentage of encapsulant in the resulting encapsulated particles is between about 20 to about 80%.

16.	The method of claim 1 wherein the sensitive material is a volatile material.

17.	The method of claim 1 wherein the sensitive material is an oxygen sensitive material.

18.	The method of claim 1 wherein the sensitive material is a biologically active substance.

19.	The method of claim 18 wherein the biologically active substance is selected from the group consisting of Lactobacilli, Bifidobacterium, Enterococci, phytase, amylases, lipases, invertases, transglutaminases, proteases, lipoxygenases and pentosanases.

20.	The method of claim 1 wherein the sensitive material is at least one selected from the group consisting of alcohols, acetones, ketones, aldehydes, organic acids, and antioxidants.

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