Title:
SEPARATING COLUMN FOR HIPPURIC ACID ANALYSIS, LIQUID CHROMATOGRAPH FOR HIPPURIC ACID ANALYSIS, AND METHOD FOR ANALYZING HIPPURIC ACID
Document Type and Number:
WIPO Patent Application WO/2019/198280
Kind Code:
A1
Abstract:
This separating column (12) for hippuric acid analysis is filled with a filler in which 123 μmol/g or more of β-cyclodextrin is chemically bonded to a silica matrix. By using such a filler for the separating column (12) in which 123 μmol/g or more of β-cyclodextrin is chemically bonded to a silica matrix, it is possible to separate a hippuric acid, an o-methyl hippuric acid, a m-methyl hippuric acid, a p-methyl hippuric acid, and a mandelic acid without using a mobile phase containing cyclodextrin.
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Inventors:
TAMAGUCHI TADAYUKI (JP)
FUJIMURA DAIKI (JP)
OTSUKI HIDEYUKI (JP)
FUJIMURA DAIKI (JP)
OTSUKI HIDEYUKI (JP)
Application Number:
PCT/JP2018/048473
Publication Date:
October 17, 2019
Filing Date:
December 28, 2018
Export Citation:
Assignee:
SHIMADZU CORP (JP)
International Classes:
G01N30/88; B01J20/283; B01J20/285; G01N30/26; G01N30/72; G01N27/62
Foreign References:
| JPH07225225A | 1995-08-22 | |||
| JP2010037261A | 2010-02-18 | |||
| JPH07113797A | 1995-05-02 |
Other References:
MATSUI, HISAO ET AL.: "High-performance liquid chromatographic separation of urinary hippuric and o-, m- and p-methylhippuric acids with a beta- cyclodextrin-bonded column", JOURNAL OF CHROMATOGRAPHY, vol. 496, 1989, pages 189 - 193, XP026728345, DOI: 10.1016/S0378-4347(00)82565-7
ANONYMOUS: "CYCLOBOND Series HPLC Column Operating Instructions", 1 January 2006 (2006-01-01), pages 1 - 3, XP055642852, Retrieved from the Internet [retrieved on 20190301]
SAITO, TAKESHI ET AL.: "Simultaneous detection of hippuric acid and methylhippuric acid in urine by empore disk and gas chromatography-mass spectrometry", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 30, no. 2, 1 September 2002 (2002-09-01), pages 365 - 370, XP055642853, ISSN: 0731-7085, DOI: 10.1016/S0731-7085(02)00268-6
SAKAI, TADASHI ET AL.: "Simultaneous determination of hippuric acid and o-, m-and p-methylhippuric acids in urine by high-performance liquid chromatography", JOURNAL OF CHROMATOGRAPHY, vol. 276, 1 January 1983 (1983-01-01), pages 182 - 188, XP026727641, DOI: 10.1016/S0378-4347(00)85080-X
LI, X. M. ET AL.: "Design of a ruthenium (III) immobilized affinity material based on a beta - cyclodextrin-functionalized poly (glycidyl methacrylate-ethylene dimethacrylate) monolith for the enrichment of hippuric acid", JOURNAL OF SEPARATION SCIENCE, vol. 40, no. 18, 26 June 2017 (2017-06-26), pages 3696 - 3702, XP055642854, DOI: 10.1002/jssc.201700436
ANONYMOUS: "CYCLOBOND Series HPLC Column Operating Instructions", 1 January 2006 (2006-01-01), pages 1 - 3, XP055642852, Retrieved from the Internet
SAITO, TAKESHI ET AL.: "Simultaneous detection of hippuric acid and methylhippuric acid in urine by empore disk and gas chromatography-mass spectrometry", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 30, no. 2, 1 September 2002 (2002-09-01), pages 365 - 370, XP055642853, ISSN: 0731-7085, DOI: 10.1016/S0731-7085(02)00268-6
SAKAI, TADASHI ET AL.: "Simultaneous determination of hippuric acid and o-, m-and p-methylhippuric acids in urine by high-performance liquid chromatography", JOURNAL OF CHROMATOGRAPHY, vol. 276, 1 January 1983 (1983-01-01), pages 182 - 188, XP026727641, DOI: 10.1016/S0378-4347(00)85080-X
LI, X. M. ET AL.: "Design of a ruthenium (III) immobilized affinity material based on a beta - cyclodextrin-functionalized poly (glycidyl methacrylate-ethylene dimethacrylate) monolith for the enrichment of hippuric acid", JOURNAL OF SEPARATION SCIENCE, vol. 40, no. 18, 26 June 2017 (2017-06-26), pages 3696 - 3702, XP055642854, DOI: 10.1002/jssc.201700436
Attorney, Agent or Firm:
NOGUCHI Daisuke (JP)
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