SEPARATION AND PURIFICATION METHOD FOR EPIRUBICIN OR HYDROCHLORIDE THEREOF

Title:

SEPARATION AND PURIFICATION METHOD FOR EPIRUBICIN OR HYDROCHLORIDE THEREOF

Document Type and Number:

WIPO Patent Application WO/2017/075994

Kind Code:

A1

Abstract:

Provided are a separation and purification method for epirubicin or hydrochloride thereof. The method comprises: 1) taking epirubicin or a hydrochloride crude product thereof, and sampling macroporous absorption resin; and 2) carrying out elution by using an organic solvent water solution at a volume percent of 5% to 50%, collecting and combining an eluent, and carrying out separation to obtain epirubicin. The method is economical and efficient, and has very good selectivity and a very good separation effect on purities of epirubicin or hydrochloride thereof, epirubicin hydrochloride of a pharmaceutical-grade purity can be obtained by performing separation and purification for one time, and the yield is high.

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Inventors:

ZHANG FULI (CN)
JIA MIAO (CN)
QIU PENGCHENG (CN)
NI GUOWEI (CN)
ZHU JINJIN (CN)
WANG YOUGUI (CN)
MAO WENGANG (CN)
YAN WEI (CN)

Application Number:

PCT/CN2016/085105

Publication Date:

May 11, 2017

Filing Date:

June 07, 2016

Export Citation:

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Assignee:

ZHEJIANG HISUN PHARM CO LTD (CN)
SHANGHAI INST PHARMACEUTICAL IND (CN)

International Classes:

C07H15/252; C07H1/06

Foreign References:

JP2000351791A	2000-12-19
CN103087124A	2013-05-08

Other References:

JIAN, MIAO ET AL.: "Synthesis of Epirubicin Hydrochloride", CHINESE JOURNAL OF PHARMACEUTICALS, vol. 47, no. 5, 25 May 2016 (2016-05-25), pages 522 - 527, ISSN: 1001-8255
JIAN, MIAO ET AL.: "Purification of Epirubicin Hydrochloride by Macroporous resin", CHINE JOURNAL OF ANTIBIOTICS, vol. 41, no. 4, 30 April 2016 (2016-04-30), pages 271 - 276, ISSN: 1001-8689

Attorney, Agent or Firm:

SHANGHAI BESHINING LAW OFFICE (CN)

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